Acetic acid 1-acetoxy-12-tert-butyl-7-[5-tert-butyl-2-(dimethoxy-phosphorylmethyl)-3-methyl-phenyl]-10-methyl-7b-oxo-7bH,9H-8-oxa-7bλ⁵-phospha-benzo[6,7]cyclohepta[1,2,3-jk]fluoren-6-yl ester

Base Information

• Chemical Name: Acetic acid 1-acetoxy-12-tert-butyl-7-[5-tert-butyl-2-(dimethoxy-phosphorylmethyl)-3-methyl-phenyl]-10-methyl-7b-oxo-7bH,9H-8-oxa-7bλ⁵-phospha-benzo[6,7]cyclohepta[1,2,3-jk]fluoren-6-yl ester
• CAS No.: 186706-95-6
• Molecular Formula: C₄₂H₄₈O₉P₂
• Molecular Weight: 758.785

Synonyms:

Chemical Property of Acetic acid 1-acetoxy-12-tert-butyl-7-[5-tert-butyl-2-(dimethoxy-phosphorylmethyl)-3-methyl-phenyl]-10-methyl-7b-oxo-7bH,9H-8-oxa-7bλ⁵-phospha-benzo[6,7]cyclohepta[1,2,3-jk]fluoren-6-yl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Acetic acid 1-acetoxy-12-tert-butyl-7-[5-tert-butyl-2-(dimethoxy-phosphorylmethyl)-3-methyl-phenyl]-10-methyl-7b-oxo-7bH,9H-8-oxa-7bλ⁵-phospha-benzo[6,7]cyclohepta[1,2,3-jk]fluoren-6-yl ester

There total 1 articles about Acetic acid 1-acetoxy-12-tert-butyl-7-[5-tert-butyl-2-(dimethoxy-phosphorylmethyl)-3-methyl-phenyl]-10-methyl-7b-oxo-7bH,9H-8-oxa-7bλ⁵-phospha-benzo[6,7]cyclohepta[1,2,3-jk]fluoren-6-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

meso-4,6-Bis(2-bromomethyl-3-methyl-5-tert-butylphenyl)-5-methoxy-5-oxo-5H-5λ5-phosphole-3,7-diyl diacetate (112921-26-3) + phosphorous acid trimethyl ester (121-45-9) → meso-4,6-Bis(2-dimethoxyphosphorylmethyl-3-methyl-5-tert-butylphenyl)-5-methoxy-5-oxo-5H-5λ5-dibenzophosphole-3,7-diyl diacetate (186776-81-8,112921-27-4) + Acetic acid 1-acetoxy-12-tert-butyl-7-[5-tert-butyl-2-(dimethoxy-phosphorylmethyl)-3-methyl-phenyl]-10-methyl-7b-oxo-7bH,9H-8-oxa-7bλ5-phospha-benzo[6,7]cyclohepta[1,2,3-jk]fluoren-6-yl ester (186706-95-6)

Guidance literature:

at 115 ℃; for 20h; Yield given. Yields of byproduct given;

DOI:10.1039/P19960002889

Reference yield:

Acetic acid 1-acetoxy-12-tert-butyl-7-[5-tert-butyl-2-(dimethoxy-phosphorylmethyl)-3-methyl-phenyl]-10-methyl-7b-oxo-7bH,9H-8-oxa-7bλ5-phospha-benzo[6,7]cyclohepta[1,2,3-jk]fluoren-6-yl ester (186706-95-6) → {4-tert-Butyl-2-[6-(5-tert-butyl-2,3-dimethyl-phenyl)-5-hydroxy-5-oxo-3,7-bis-phosphonomethoxy-5H-5λ5-dibenzophosphol-4-yl]-6-methyl-benzyl}-phosphonic acid

Guidance literature:

Multi-step reaction with 4 steps

1: aq. NaOH / methanol / 0.02 h

2: NaH, HMPA / benzene / 18 h / 44 °C

3: iodotrimethylsilane / CHCl₃ / 25 h

4: 1.) Zn, Cu, 2.) H₂ / 2.) 10percent Pd/C / 1.) MeOH, overnight, 2.) MeOH, 1 atm, overnight

With N,N,N,N,N,N-hexamethylphosphoric triamide; sodium hydroxide; trimethylsilyl iodide; hydrogen; copper; sodium hydride; zinc; palladium on activated charcoal; In methanol; chloroform; benzene;

DOI:10.1039/P19960002889

Reference yield:

Acetic acid 1-acetoxy-12-tert-butyl-7-[5-tert-butyl-2-(dimethoxy-phosphorylmethyl)-3-methyl-phenyl]-10-methyl-7b-oxo-7bH,9H-8-oxa-7bλ5-phospha-benzo[6,7]cyclohepta[1,2,3-jk]fluoren-6-yl ester (186706-95-6) → {4-tert-Butyl-2-[6-(5-tert-butyl-2-iodomethyl-3-methyl-phenyl)-5-hydroxy-5-oxo-3,7-bis-phosphonomethoxy-5H-5λ5-dibenzophosphol-4-yl]-6-methyl-benzyl}-phosphonic acid (186707-01-7)

Guidance literature:

Multi-step reaction with 3 steps

1: aq. NaOH / methanol / 0.02 h

2: NaH, HMPA / benzene / 18 h / 44 °C

3: iodotrimethylsilane / CHCl₃ / 25 h

With N,N,N,N,N,N-hexamethylphosphoric triamide; sodium hydroxide; trimethylsilyl iodide; sodium hydride; In methanol; chloroform; benzene;

DOI:10.1039/P19960002889

upstream raw materials:

meso-4,6-Bis(2-bromomethyl-3-methyl-5-tert-butylphenyl)-5-methoxy-5-oxo-5H-5λ⁵-phosphole-3,7-diyl diacetate

phosphorous acid trimethyl ester

Downstream raw materials:

{4-tert-Butyl-2-[6-(5-tert-butyl-2-iodomethyl-3-methyl-phenyl)-5-hydroxy-5-oxo-3,7-bis-phosphonomethoxy-5H-5λ⁵-dibenzophosphol-4-yl]-6-methyl-benzyl}-phosphonic acid

{4-tert-Butyl-2-[12-tert-butyl-1,6-bis-(diethoxy-phosphorylmethoxy)-10-methyl-7b-oxo-7bH,9H-8-oxa-7bλ⁵-phospha-benzo[6,7]cyclohepta[1,2,3-jk]fluoren-7-yl]-6-methyl-benzyl}-phosphonic acid dimethyl ester

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