4-[(1R)-2-((6-[4-(1,1-dioxido-2,3-dihydrobenzothiophen-6-yl)butoxy]hexyl)amino)-1-hydroxyethyl]-2-(hydroxymethyl)phenol acetate salt

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Chemical Name:4-[(1R)-2-((6-[4-(1,1-dioxido-2,3-dihydrobenzothiophen-6-yl)butoxy]hexyl)amino)-1-hydroxyethyl]-2-(hydroxymethyl)phenol acetate salt
CAS No.:1520073-15-7
Molecular Formula:C₂H₄O₂*C₂₇H₃₉NO₆S
Molecular Weight:565.728
Hs Code.:

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Chemical Property of 4-[(1R)-2-((6-[4-(1,1-dioxido-2,3-dihydrobenzothiophen-6-yl)butoxy]hexyl)amino)-1-hydroxyethyl]-2-(hydroxymethyl)phenol acetate salt

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Technology Process of 4-[(1R)-2-((6-[4-(1,1-dioxido-2,3-dihydrobenzothiophen-6-yl)butoxy]hexyl)amino)-1-hydroxyethyl]-2-(hydroxymethyl)phenol acetate salt

There total 5 articles about 4-[(1R)-2-((6-[4-(1,1-dioxido-2,3-dihydrobenzothiophen-6-yl)butoxy]hexyl)amino)-1-hydroxyethyl]-2-(hydroxymethyl)phenol acetate salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 21.0%

: 208925-08-0
(2R)-hydroxy-2-(2,2-dimethyl-4H-1,3-benzodioxine-6-yl)-ethylamine

: 855997-34-1
6-{4-[(6-bromohexyl)oxy]butyl}-2,3-dihydro-1-benzothiophene 1,1-dioxide

: 855997-40-9
6-{4-[(6-iodohexyl)oxy]butyl}-2,3-dihydro-1-benzothiophene 1,1-dioxide

: 64-19-7,77671-22-8
acetic acid

: 1520073-15-7
4-[(1R)-2-((6-[4-(1,1-dioxido-2,3-dihydrobenzothiophen-6-yl)butoxy]hexyl)amino)-1-hydroxyethyl]-2-(hydroxymethyl)phenol acetate salt

Guidance literature:: In water; N,N-dimethyl-formamide; at 20 - 65 ℃; for 0.25h;
DOI:10.1021/jm401532g

Reference yield:

: 629-03-8
1 ,6-dibromohexane

: 1520073-15-7
4-[(1R)-2-((6-[4-(1,1-dioxido-2,3-dihydrobenzothiophen-6-yl)butoxy]hexyl)amino)-1-hydroxyethyl]-2-(hydroxymethyl)phenol acetate salt

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydroxide; tetrabutylammomium bromide / 18 h / 20 °C / Inert atmosphere

2.1: 9-bora-bicyclo[3.3.1]nonane / tetrahydrofuran / 2 h / 20 °C / Inert atmosphere

2.2: 2 h / 65 °C / Inert atmosphere

3.1: water; N,N-dimethyl-formamide / 0.25 h / 20 - 65 °C

With tetrabutylammomium bromide; 9-bora-bicyclo[3.3.1]nonane; sodium hydroxide; In tetrahydrofuran; water; N,N-dimethyl-formamide;
DOI:10.1021/jm401532g

Reference yield:

: 19983-44-9
stattic

: 1520073-15-7
4-[(1R)-2-((6-[4-(1,1-dioxido-2,3-dihydrobenzothiophen-6-yl)butoxy]hexyl)amino)-1-hydroxyethyl]-2-(hydroxymethyl)phenol acetate salt

Guidance literature:: Multi-step reaction with 4 steps

1.1: hydrogen; palladium 10% on activated carbon / ethyl acetate; acetic acid

2.1: hydrogenchloride; sodium nitrite / water / 0.25 h

2.2: 0.5 h / 65 °C

3.1: 9-bora-bicyclo[3.3.1]nonane / tetrahydrofuran / 2 h / 20 °C / Inert atmosphere

3.2: 2 h / 65 °C / Inert atmosphere

4.1: water; N,N-dimethyl-formamide / 0.25 h / 20 - 65 °C

With hydrogenchloride; palladium 10% on activated carbon; hydrogen; 9-bora-bicyclo[3.3.1]nonane; sodium nitrite; In tetrahydrofuran; water; acetic acid; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/jm401532g