4-Methylpiperidin-4-OL

Base Information

• Chemical Name: 4-Methylpiperidin-4-OL
• CAS No.: 3970-68-1
• Molecular Formula: C6H13NO
• Molecular Weight: 115.175
• Hs Code.: 2933399090
• European Community (EC) Number: 813-671-7
• DSSTox Substance ID: DTXSID30576304
• Wikidata: Q72495842
• Mol file: 3970-68-1.mol

Synonyms:4-METHYLPIPERIDIN-4-OL;3970-68-1;4-Methyl-piperidin-4-ol;4-HYDROXY-4-METHYLPIPERIDINE;MFCD11100993;4-methyl-4-piperidinol;4-PIPERIDINOL, 4-METHYL-;4-methylpiperid-4-ol;Hydroxy-4-methylpiperidine;SCHEMBL86857;4-methyl-4-hydroxypiperidine;4-hydroxy-4 methyl-piperidine;4-hydroxy-4-methyl-piperidine;DTXSID30576304;AKOS012081783;CS-W004838;PB10877;AM100764;DS-17620;SY008477;A6631;EN300-111829;J-515808;4-OXO-4-[N-(PYRIDINE-4-CARBONYL)-HYDRAZINO]-BUTYRICACID

Chemical Property of 4-Methylpiperidin-4-OL

Chemical Property:

• Vapor Pressure: 0.209mmHg at 25°C
• Refractive Index: 1.465
• Boiling Point: 184.425 °C at 760 mmHg
• PKA: 15.01±0.20(Predicted)
• Flash Point: 79.471 °C
• PSA: 32.26000
• Density: 0.977 g/cm³
• LogP: 0.44960
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• XLogP3: -0.1
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 0
• Exact Mass: 115.099714038
• Heavy Atom Count: 8
• Complexity: 76.6

Purity/Quality:

99.0% ^*data from raw suppliers

4-Methylpiperidin-4-ol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1(CCNCC1)O

Technology Process of 4-Methylpiperidin-4-OL

There total 9 articles about 4-Methylpiperidin-4-OL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

1-benzyl-4-methyl-piperidin-4-ol (3970-66-9) → 4-methylpiperidin-4-ol (3970-68-1)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; at 22 ℃; for 19.5h; under 3102.97 Torr;

Reference yield: 99.0%

tert-butyl 4-hydroxy-4-methylpiperidine-1-carboxylate (406235-30-1) → 4-methylpiperidin-4-ol (3970-68-1)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 1h;

Reference yield: 72.0%

benzyl 4-hydroxy-4-methylpiperidine-1-carboxylate (169750-57-6) → 4-methylpiperidin-4-ol (3970-68-1)

Guidance literature:

With palladium on activated charcoal; hydrogen; In methanol; at 20 ℃; under 2585.81 Torr; Inert atmosphere;

upstream raw materials:

benzyl 4-hydroxy-4-methylpiperidine-1-carboxylate

1-benzyl-4-methyl-piperidin-4-ol

N-tert-butyloxycarbonylpiperidin-4-one

tert-butyl 4-hydroxy-4-methylpiperidine-1-carboxylate

Downstream raw materials:

(S)-1-phenylethyl (2S)-2-(4-hydroxy-4-methylpiperidin-1-yl)-2-phenylacetate

(S)-1-phenylethyl (R)-2-(4-hydroxy-4-methylpiperidin-1-yl)-2-phenylacetate

1-[(E)-3-(4-bromo-phenyl)-allyl]-4-methyl-piperidin-4-ol

1-[(E)-3-(4-iodo-phenyl)-2-methyl-allyl]-4-methyl-piperidin-4-ol