(S)-1-phenylethyl (R)-2-(4-hydroxy-4-methylpiperidin-1-yl)-2-phenylacetate

Base Information

Chemical Name:(S)-1-phenylethyl (R)-2-(4-hydroxy-4-methylpiperidin-1-yl)-2-phenylacetate
CAS No.:1007878-24-1
Molecular Formula:C₂₂H₂₇NO₃
Molecular Weight:353.461
Hs Code.:

Synonyms:(S)-1-phenylethyl (R)-2-(4-hydroxy-4-methylpiperidin-1-yl)-2-phenylacetate

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Chemical Property of (S)-1-phenylethyl (R)-2-(4-hydroxy-4-methylpiperidin-1-yl)-2-phenylacetate

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Technology Process of (S)-1-phenylethyl (R)-2-(4-hydroxy-4-methylpiperidin-1-yl)-2-phenylacetate

There total 7 articles about (S)-1-phenylethyl (R)-2-(4-hydroxy-4-methylpiperidin-1-yl)-2-phenylacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 3970-68-1
4-methylpiperidin-4-ol

: 1007878-22-9
(S)-1-phenylethyl 2-bromo-2-phenylacetate

: 1007878-26-3
(S)-1-phenylethyl (2S)-2-(4-hydroxy-4-methylpiperidin-1-yl)-2-phenylacetate

: 1007878-24-1
(S)-1-phenylethyl (R)-2-(4-hydroxy-4-methylpiperidin-1-yl)-2-phenylacetate

Guidance literature:: (S)-1-phenylethyl 2-bromo-2-phenylacetate; With triethylamine; tetra-(n-butyl)ammonium iodide; In tetrahydrofuran; at 20 ℃; for 0.0833333h;

4-methylpiperidin-4-ol; In tetrahydrofuran; at 20 - 60 ℃; for 5h;

Reference yield: 60.0%

: 3970-68-1
4-methylpiperidin-4-ol

: 1007878-22-9
(S)-1-phenylethyl 2-bromo-2-phenylacetate

: 1007878-24-1
(S)-1-phenylethyl (R)-2-(4-hydroxy-4-methylpiperidin-1-yl)-2-phenylacetate

Guidance literature:: (S)-1-phenylethyl 2-bromo-2-phenylacetate; With tetra-(n-butyl)ammonium iodide; triethylamine; In tetrahydrofuran; at 20 ℃; for 0.0833333h;

4-methylpiperidin-4-ol; In tetrahydrofuran; at 55 - 60 ℃; for 5h;

Reference yield: 60.0%

: 3970-68-1
4-methylpiperidin-4-ol

: 1007878-26-3
(S)-1-phenylethyl (2S)-2-(4-hydroxy-4-methylpiperidin-1-yl)-2-phenylacetate

: 1007878-24-1
(S)-1-phenylethyl (R)-2-(4-hydroxy-4-methylpiperidin-1-yl)-2-phenylacetate

Guidance literature:: (S)-1-phenylethyl 2-bromo-2-phenylacetate; With tetra-(n-butyl)ammonium iodide; triethylamine; In tetrahydrofuran; at 20 ℃; for 0.0833333h;

4-methylpiperidin-4-ol; In tetrahydrofuran; at 20 - 60 ℃; for 5h;