169750-57-6

Basic information

• Product Name: 4-Hydroxy-4-methylpiperidine-1-carboxylic acid benzyl ester
• Synonyms: 4-Hydroxy-4-methylpiperidine-1-carboxylic acid benzyl ester;N-CBZ-4-Hydroxy-4-Methylpiperidine;Benzyl 4-hydroxy-4-methylpiperidine-1-carboxylate;1-Piperidinecarboxylicacid, 4-hydroxy-4-methyl-, phenylmethyl ester;1-Cbz-4-hydroxy-4-methylpiperidine
• CAS NO: 169750-57-6
• Molecular Formula: C₁₄H₁₉NO₃
• Molecular Weight: 249.31
• Product Categories: pharmacetical
• Mol File: 169750-57-6.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 383.9°Cat760mmHg
• Flash Point: 186°C
• Appearance: /
• Density: 1.18g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.56
• CAS DataBase Reference: 4-Hydroxy-4-methylpiperidine-1-carboxylic acid benzyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Hydroxy-4-methylpiperidine-1-carboxylic acid benzyl ester(169750-57-6)
• EPA Substance Registry System: 4-Hydroxy-4-methylpiperidine-1-carboxylic acid benzyl ester(169750-57-6)

Safety Data

• Hazardous Substances Data: 169750-57-6(Hazardous Substances Data)

Usage

General Description

4-Hydroxy-4-methylpiperidine-1-carboxylic acid benzyl ester is a chemical compound with the molecular formula C15H21NO3. It is an ester derivative of 4-hydroxy-4-methylpiperidine-1-carboxylic acid, and is commonly used in the pharmaceutical industry as an intermediate in the synthesis of various drugs. 4-Hydroxy-4-methylpiperidine-1-carboxylic acid benzyl ester has potential applications in the development of pharmaceuticals for the treatment of various medical conditions. It is important to handle and store this compound with care, as it may be hazardous if not handled properly. Overall, 4-Hydroxy-4-methylpiperidine-1-carboxylic acid benzyl ester is an important compound in medicinal chemistry with potential therapeutic applications.

InChI:InChI=1/C14H19NO3/c1-14(17)7-9-15(10-8-14)13(16)18-11-12-5-3-2-4-6-12/h2-6,17H,7-11H2,1H3

Upstream product

• 19099-93-5 benzyl 4-oxo-1-piperidinecarboxylate 
• 501-53-1 benzyl chloroformate 
• 75-16-1 methylmagnesium bromide 
• 676-58-4 methylmagnesium chloride 
• 917-54-4 methyllithium 
• 626-58-4 4-methylpiperidin 
• 217795-77-2 N-benzyloxycarbonyl-4-methylpiperidine 

Downstream Products

• 1236404-84-4 N-{3-[(4-hydroxy-4-methylpiperidin-1-yl)methyl]-8-methylquinolin-7-yl}-4-(tetrahydrofuran-3-ylmethoxy)benzamide 
• 1236404-94-6 N-{3-[(4-hydroxy-4-methylpiperidin-1-yl)methyl]-8-methylquinolin-7-yl}-4-[(2S)-tetrahydrofuran-2-ylmethoxy]benzamide 
• 3970-68-1 4-methylpiperidin-4-ol 

Relevant articles and documents

Design, synthesis, and in vitro bioactivity evaluation of fluorine-containing analogues for sphingosine-1-phosphate 2 receptor

Twenty eight new aryloxybenzene analogues were synthesized and their in vitro binding potencies toward S1PR2 were determined using a [32P]S1P competitive binding assay. Out of these new analogues, three compounds, 28c (IC50 = 29.9 ± 3.9 nM), 28e (IC50 = 14.6 ± 1.5 nM), and 28g (IC50 = 38.5 ± 6.3 nM) exhibited high binding potency toward S1PR2 and high selectivity over the other four receptor subtypes (S1PR1, 3, 4, and 5; IC50 > 1000 nM). Each of the three potent compounds 28c, 28e, and 28g contains a fluorine atom that will allow to develop F-18 labeled PET radiotracers for imaging S1PR2.

IMIDAZOLE DERIVATIVES AND METHODS OF USE THEREOF FOR IMPROVING PHARMACOKINETICS OF DRUG

Imidazole derivatives of formula (I), pharmaceutically acceptable salts thereof and pharmaceutical compositions comprising at least one imidazole derivative are disclosed. The imidazole derivatives are effective to inhibit CYP450 3A and can be used to improve the pharmacokinetics of a drug that is metabolized by CYP450 3A4.

QUINOLINE DERIVATIVE

The present invention provides a compound having a melanin-concentrating hormone receptor antagonistic action and low toxicity, which is useful as an agent for the prophylaxis or treatment of obesity and the like. The present invention relates to a compound represented by the formula (I): wherein each symbol is as defined in the specification, or a salt thereof.