2-(cyclohexyloxy)aniline

Base Information

• Chemical Name: 2-(cyclohexyloxy)aniline
• CAS No.: 105973-37-3
• Molecular Formula: C12H17NO
• Molecular Weight: 191.273
• Hs Code.: 2922299090
• Mol file: 105973-37-3.mol

Synonyms:2-cyclohexyloxy-phenylamine;2-cyclohexyloxyaniline;2-cyclohexyloxy-1,1,3,3-tetramethylisoindoline;2-cyclohexyloxy-1,1,3,3-tetramethyl-2,3-dihydro-1H-isoindole;2-Aminophenyl-cyclohexylaether;

Chemical Property of 2-(cyclohexyloxy)aniline

Chemical Property:

• Melting Point: 55-56 °C
• Boiling Point: 318.3±15.0 °C(Predicted)
• PKA: 4.45±0.10(Predicted)
• PSA: 35.25000
• Density: 1.073±0.06 g/cm3(Predicted)
• LogP: 3.56150

Purity/Quality:

97% ^*data from raw suppliers

2-(Cyclohexyloxy)aniline 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-(cyclohexyloxy)aniline

There total 4 articles about 2-(cyclohexyloxy)aniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

→ 2-(Cyclohexyloxy)-aniline (105973-37-3)

Guidance literature:

Reference yield: 94.0%

2-cyclohexyloxynitrobenzene (30718-74-2) → 2-(Cyclohexyloxy)-aniline (105973-37-3)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In ethanol; for 2h; under 2068.65 Torr;

DOI:10.1021/ol201657p

Reference yield:

cyclohexanol (108-93-0) → 2-(Cyclohexyloxy)-aniline (105973-37-3)

Guidance literature:

Multi-step reaction with 2 steps

1.1: KH / tetrahydrofuran / 16 h / 20 °C

1.2: 78 percent / tetrahydrofuran / 2 h / -78 - 20 °C

2.1: 83 percent / N₂H₄*H₂O / Pd(10 wt percent)/C / ethanol / 1 h / Heating

With potassium hydride; hydrazine hydrate; palladium on activated carbon; In tetrahydrofuran; ethanol;

DOI:10.1016/S0022-328X(03)00790-3

upstream raw materials:

2-cyclohexyloxynitrobenzene

ortho-nitrofluorobenzene

cyclohexanol

Downstream raw materials:

2-cyclohexyloxy-N-cyclohexylaniline

C₄₅H₃₅NO₄

N_.N-Bis-(2-hydroxyaethyl)-2-cyclohexyloxy-anilin