Technology Process of 4,7-difluoro-5,6-<(diphenylmethylene)dioxy>indole
There total 7 articles about 4,7-difluoro-5,6-<(diphenylmethylene)dioxy>indole which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
florisil; iron; acetic acid;
In
toluene;
for 1.5h;
Yield given;
Heating;
DOI:10.1021/jm00170a026
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 0.1 h / 160 °C
2: Et3N / dimethylformamide / 15 h / 120 - 130 °C
3: Fe, Florisil, acetic acid / toluene / 1.5 h / Heating
With
florisil; iron; acetic acid; triethylamine;
In
N,N-dimethyl-formamide; toluene;
DOI:10.1021/jm00170a026
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 1.) 2.5 M n-BuLi / 1.) THF, hexane, -78 deg C, 1 h, 2.) 25 deg C, 12 h
2: 71 percent / 90percent HNO3, Ac2O, H2SO4 / 0.25 h / -10 °C
3: BBr3 / CH2Cl2 / 1.) -78 deg C, 2 h, 2.) 25 deg C, 12 h
4: 0.1 h / 160 °C
5: Et3N / dimethylformamide / 15 h / 120 - 130 °C
6: Fe, Florisil, acetic acid / toluene / 1.5 h / Heating
With
florisil; n-butyllithium; sulfuric acid; nitric acid; acetic anhydride; boron tribromide; iron; acetic acid; triethylamine;
In
dichloromethane; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jm00170a026
![[(E)-2-(4,7-Difluoro-6-nitro-2,2-diphenyl-benzo[1,3]dioxol-5-yl)-vinyl]-dimethyl-amine](/Databaselist/images/loading.webp)
