Phosphoric acid (2R,3S,5R)-5-(6-benzoylamino-1-oxy-purin-9-yl)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-tetrahydro-furan-3-yl ester 2-chloro-phenyl ester 2-cyano-ethyl ester

Base Information

• Chemical Name: Phosphoric acid (2R,3S,5R)-5-(6-benzoylamino-1-oxy-purin-9-yl)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-tetrahydro-furan-3-yl ester 2-chloro-phenyl ester 2-cyano-ethyl ester
• CAS No.: 86048-99-9
• Molecular Formula: C₄₇H₄₂ClN₆O₁₀P
• Molecular Weight: 917.311

Synonyms:

Chemical Property of Phosphoric acid (2R,3S,5R)-5-(6-benzoylamino-1-oxy-purin-9-yl)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-tetrahydro-furan-3-yl ester 2-chloro-phenyl ester 2-cyano-ethyl ester

Chemical Property:

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Technology Process of Phosphoric acid (2R,3S,5R)-5-(6-benzoylamino-1-oxy-purin-9-yl)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-tetrahydro-furan-3-yl ester 2-chloro-phenyl ester 2-cyano-ethyl ester

There total 3 articles about Phosphoric acid (2R,3S,5R)-5-(6-benzoylamino-1-oxy-purin-9-yl)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-tetrahydro-furan-3-yl ester 2-chloro-phenyl ester 2-cyano-ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2'-Deoxyadenosine N1-oxide (3506-01-2) → Phosphoric acid (2R,3S,5R)-5-(6-benzoylamino-1-oxy-purin-9-yl)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-tetrahydro-furan-3-yl ester 2-chloro-phenyl ester 2-cyano-ethyl ester (86048-99-9)

Guidance literature:

DOI:10.1016/S0040-4039(00)81325-8

Reference yield:

benzoic acid anhydride (93-97-0) → Phosphoric acid (2R,3S,5R)-5-(6-benzoylamino-1-oxy-purin-9-yl)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-tetrahydro-furan-3-yl ester 2-chloro-phenyl ester 2-cyano-ethyl ester (86048-99-9)

Guidance literature:

DOI:10.1016/S0040-4039(00)81325-8

Reference yield:

N-(9-{(2R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-tetrahydro-furan-2-yl}-1-oxy-9H-purin-6-yl)-benzamide (86049-02-7) + 2-chlorophenyl phosphordi(1H-1-[1,2,4]triazolide) (72351-28-1) + 3-Hydroxypropionitrile (109-78-4) → Phosphoric acid (2R,3S,5R)-5-(6-benzoylamino-1-oxy-purin-9-yl)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-tetrahydro-furan-3-yl ester 2-chloro-phenyl ester 2-cyano-ethyl ester (86048-99-9)

Guidance literature:

Yield given. Multistep reaction;

DOI:10.1016/S0040-4039(00)81325-8

upstream raw materials:

N-(9-{(2R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-tetrahydro-furan-2-yl}-1-oxy-9H-purin-6-yl)-benzamide

2-chlorophenyl phosphordi(1H-1-[1,2,4]triazolide)

3-Hydroxypropionitrile

2'-Deoxyadenosine N¹-oxide

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