N-benzhydrylmethanesulfonamide

Base Information

• Chemical Name: N-benzhydrylmethanesulfonamide
• CAS No.: 5408-20-8
• Molecular Formula: C14H15 N O2 S
• Molecular Weight: 261.345
• Hs Code.: 2935009090
• Mol file: 5408-20-8.mol

Synonyms:N-(Diphenylmethyl)methanesulfonamide;NSC 10781

Chemical Property of N-benzhydrylmethanesulfonamide

Chemical Property:

• Vapor Pressure: 3.29E-07mmHg at 25°C
• Boiling Point: 418.4°C at 760 mmHg
• Flash Point: 206.8°C
• PSA: 54.55000
• Density: 1.21g/cm³
• LogP: 3.79690

Purity/Quality:

99% ^*data from raw suppliers

N-BENZHYDRYLMETHANESULFONAMIDE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-benzhydrylmethanesulfonamide

There total 13 articles about N-benzhydrylmethanesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

methanesulfonyl chloride (124-63-0) + Benzhydrylamine (91-00-9) → N-(diphenylmethyl)methanesulfonamide (5408-20-8)

Guidance literature:

With triethylamine; In dichloromethane;

DOI:10.1016/S0040-4039(00)60168-5

Reference yield: 98.0%

methanesulfonamide (3144-09-0) + Diphenylmethane (101-81-5) → N-(diphenylmethyl)methanesulfonamide (5408-20-8)

Guidance literature:

With [bis(acetoxy)iodo]benzene; iodine; at 50 ℃; Inert atmosphere;

DOI:10.1021/ol900090f

Reference yield: 93.0%

1,1-Diphenylmethanol (91-01-0) + methanesulfonamide (3144-09-0) → N-(diphenylmethyl)methanesulfonamide (5408-20-8)

Guidance literature:

With phosphotungstic acid 44-hydrate; In 1,4-dioxane; at 80 ℃; for 12h;

DOI:10.1002/ejoc.200800413

upstream raw materials:

1,1-Diphenylmethanol

methanesulfonamide

methanesulfonyl chloride

Benzhydrylamine

Downstream raw materials:

C₁₇H₁₉NO₄S

4-[(benzhydryl-sulfamoyl)-methyl]-4-hydroxy-piperidine-1-carboxylic acid tert-butyl ester

2-benzhydryl-3-octyl-3H-inden-5-yl-4-methylbenzenesulfonate

1,3,3-triphenylpropyne

Refernces

• 1、 Cheruku, Srinivas,Manikyanally, Kumara N.,Mantelingu, Kempegowda,Nagarakere, Sandhya C.,Narayana, Yatheesh,Rangappa, Kanchugarakoppal S.,Sunilkumar, Makanahalli P.. "An expedient, efficient and solvent-free synthesis of T3P-mediated amidation of benzhydrols with poorly reactive N-nucleophiles under MW irradiation". . p. 4421 - 4426. Retrieved 2022/03/14.
• 2、 Yang, Zhenyu,Ni, Yuxin,Liu, Rui,Song, Kaixuan,Lin, Shaohui,Pan, Qinmin. "In situ generated cationic Pd(II)/bipyridine-catalyzed addition of arylboronic acids to N-sulfonyl-arylaldimines". supporting information. p. 2034 - 2037. Retrieved 2017/05/04.