N-{4-[(4-aminocyclohexyl)methyl]cyclohexyl}-N-(3-ethoxy-4-methoxybenzyl)-4-[2-(4-hydroxybenzyl)-1H-indol-3-yl]butanamide trifluoroacetic acid salt

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Chemical Name:N-{4-[(4-aminocyclohexyl)methyl]cyclohexyl}-N-(3-ethoxy-4-methoxybenzyl)-4-[2-(4-hydroxybenzyl)-1H-indol-3-yl]butanamide trifluoroacetic acid salt
CAS No.:949591-51-9
Molecular Formula:C₂HF₃O₂*C₄₂H₅₅N₃O₄
Molecular Weight:779.94
Hs Code.:

N-{4-[(4-aminocyclohexyl)methyl]cyclohexyl}-N-(3-ethoxy-4-methoxybenzyl)-4-[2-(4-hydroxybenzyl)-1H-indol-3-yl]butanamide trifluoroacetic acid salt

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Chemical Property of N-{4-[(4-aminocyclohexyl)methyl]cyclohexyl}-N-(3-ethoxy-4-methoxybenzyl)-4-[2-(4-hydroxybenzyl)-1H-indol-3-yl]butanamide trifluoroacetic acid salt

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Technology Process of N-{4-[(4-aminocyclohexyl)methyl]cyclohexyl}-N-(3-ethoxy-4-methoxybenzyl)-4-[2-(4-hydroxybenzyl)-1H-indol-3-yl]butanamide trifluoroacetic acid salt

There total 2 articles about N-{4-[(4-aminocyclohexyl)methyl]cyclohexyl}-N-(3-ethoxy-4-methoxybenzyl)-4-[2-(4-hydroxybenzyl)-1H-indol-3-yl]butanamide trifluoroacetic acid salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 10.0%

: 4.4'-methylenebis(cyclohexylamine)

: 133-32-4
4-indol-3-yl-butyric acid

: 1131-52-8
3-ethoxy-4-methoxybenzaldehyde

: 76-05-1
trifluoroacetic acid

: 949591-49-5
N-{4-[(4-aminocyclohexyl)methyl]cyclohexyl}-N-(3-ethoxy-4-methoxybenzyl)-4-(1H-indol-3-yl)butanamide trifluoroacetic acid salt

: 949591-51-9
N-{4-[(4-aminocyclohexyl)methyl]cyclohexyl}-N-(3-ethoxy-4-methoxybenzyl)-4-[2-(4-hydroxybenzyl)-1H-indol-3-yl]butanamide trifluoroacetic acid salt

Guidance literature:: Multistep reaction.;
DOI:10.1016/j.bmc.2007.06.003

Reference yield:

: 133-32-4
4-indol-3-yl-butyric acid

: 76-05-1
trifluoroacetic acid

: 949591-49-5
N-{4-[(4-aminocyclohexyl)methyl]cyclohexyl}-N-(3-ethoxy-4-methoxybenzyl)-4-(1H-indol-3-yl)butanamide trifluoroacetic acid salt

: 949591-51-9
N-{4-[(4-aminocyclohexyl)methyl]cyclohexyl}-N-(3-ethoxy-4-methoxybenzyl)-4-[2-(4-hydroxybenzyl)-1H-indol-3-yl]butanamide trifluoroacetic acid salt

Guidance literature:: [{4-[(4-{[3-ethoxy-4-methoxybenzylidene]amino}cyclohexyl)methyl]cyclohexyl}aminocarbonyloxy](Wang resin); With sodium cyanoborohydride; acetic acid; trimethyl orthoformate; at 20 ℃; for 0.0833333h;

4-indol-3-yl-butyric acid; With N-ethyl-N,N-diisopropylamine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate; In dichloromethane; at 20 ℃; for 20h;

trifluoroacetic acid; With chlorotriisopropylsilane; ethane-1,2-dithiol; In water; at 20 ℃; for 1h; Further stages.;
DOI:10.1016/j.bmc.2007.06.003