6-Methyl-4-(trifluoromethyl)pyridin-2-amine

Base Information

• Chemical Name: 6-Methyl-4-(trifluoromethyl)pyridin-2-amine
• CAS No.: 165385-89-7
• Molecular Formula: C₇H₇F₃N₂
• Molecular Weight: 176.141
• Hs Code.: 2933399990
• European Community (EC) Number: 891-527-2
• DSSTox Substance ID: DTXSID80593687
• Wikidata: Q82488210
• Mol file: 165385-89-7.mol

Synonyms:6-METHYL-4-(TRIFLUOROMETHYL)PYRIDIN-2-AMINE;165385-89-7;2-Amino-6-methyl-4-(trifluoromethyl)pyridine;6-Methyl-4-trifluoromethyl-pyridin-2-ylamine;SCHEMBL1972458;DTXSID80593687;AKOS006302511;AB60234;BS-50823;DB-292898;CS-0153239;E76563;EN300-6409004;J-010202

Chemical Property of 6-Methyl-4-(trifluoromethyl)pyridin-2-amine

Chemical Property:

• XLogP3: 1.8
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 0
• Exact Mass: 176.05613272
• Heavy Atom Count: 12
• Complexity: 157

Purity/Quality:

98%min ^*data from raw suppliers

2-Amino-6-methyl-4-(trifluoromethyl)pyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CC(=CC(=N1)N)C(F)(F)F
• Uses: 6-methyl-4-(trifluoromethyl)pyridin-2-amine is an amino pyridine derivative used in the preparation of tetrameric fructose-1,6-bisphosphatase inhibitors as well as other pharmaceutical agents.

Technology Process of 6-Methyl-4-(trifluoromethyl)pyridin-2-amine

There total 4 articles about 6-Methyl-4-(trifluoromethyl)pyridin-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.6%

N-(4-methoxybenzyl)-6-methyl-4-(trifluoromethyl)pyridin-2-amine → 6-methyl-4-(trifluoromethyl)pyridin-2-amine (165385-89-7)

Guidance literature:

With trifluoroacetic acid; at 25 ℃; for 1h;

Reference yield:

2-chloro-6-methyl-4-(trifluoromethyl)pyridine (22123-14-4) → 6-methyl-4-(trifluoromethyl)pyridin-2-amine (165385-89-7)

Guidance literature:

With ammonia; at 120 ℃; for 24h;

Reference yield:

Trimethylboroxine (823-96-1) + 6-chloro-4-(trifluoromethyl)pyridin-2-amine (34486-23-2) → 6-methyl-4-(trifluoromethyl)pyridin-2-amine (165385-89-7)

Guidance literature:

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; caesium carbonate; In 1,4-dioxane; water; at 100 ℃; for 1h; Inert atmosphere;

upstream raw materials:

2-chloro-6-methyl-4-(trifluoromethyl)pyridine

2,6-dichloro-4-(trifluoromethyl)pyridine

Trimethylboroxine

6-chloro-4-(trifluoromethyl)pyridin-2-amine

Refernces

• 1、 -. "multi-links class PI3K inhibitors (by machine translation)". . . Retrieved 2016/10/09.
• 2、 -. "NEW PYRIDINES AS FBPASE INHIBITORS FOR TREATMENT OF DIABETES". Page/Page column 32. . Retrieved 2009/06/27.