[(3aR,4S,6S,7R,7aS)-6-Methoxy-7-(4-methoxy-benzyloxy)-2,2-dimethyl-tetrahydro-[1,3]dioxolo[4,5-c]pyran-4-ylmethyl]-phosphonic acid diphenyl ester

Base Information

• Chemical Name: [(3aR,4S,6S,7R,7aS)-6-Methoxy-7-(4-methoxy-benzyloxy)-2,2-dimethyl-tetrahydro-[1,3]dioxolo[4,5-c]pyran-4-ylmethyl]-phosphonic acid diphenyl ester
• CAS No.: 135052-86-7
• Molecular Formula: C₃₀H₃₅O₉P
• Molecular Weight: 570.576
• Mol file: 135052-86-7.mol

Synonyms:

Chemical Property of [(3aR,4S,6S,7R,7aS)-6-Methoxy-7-(4-methoxy-benzyloxy)-2,2-dimethyl-tetrahydro-[1,3]dioxolo[4,5-c]pyran-4-ylmethyl]-phosphonic acid diphenyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of [(3aR,4S,6S,7R,7aS)-6-Methoxy-7-(4-methoxy-benzyloxy)-2,2-dimethyl-tetrahydro-[1,3]dioxolo[4,5-c]pyran-4-ylmethyl]-phosphonic acid diphenyl ester

There total 6 articles about [(3aR,4S,6S,7R,7aS)-6-Methoxy-7-(4-methoxy-benzyloxy)-2,2-dimethyl-tetrahydro-[1,3]dioxolo[4,5-c]pyran-4-ylmethyl]-phosphonic acid diphenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

diphenyl methyl phosphite (3577-87-5) + (3aR,4S,6S,7R,7aS)-4-Iodomethyl-6-methoxy-7-(4-methoxy-benzyloxy)-2,2-dimethyl-tetrahydro-[1,3]dioxolo[4,5-c]pyran (135052-87-8) → [(3aR,4S,6S,7R,7aS)-6-Methoxy-7-(4-methoxy-benzyloxy)-2,2-dimethyl-tetrahydro-[1,3]dioxolo[4,5-c]pyran-4-ylmethyl]-phosphonic acid diphenyl ester (135052-86-7)

Guidance literature:

at 140 ℃;

DOI:10.1039/c39910000667

Reference yield: 52.0%

isopropyl diphenyl phosphite (7330-17-8) + (3aR,4S,6S,7R,7aS)-4-Iodomethyl-6-methoxy-7-(4-methoxy-benzyloxy)-2,2-dimethyl-tetrahydro-[1,3]dioxolo[4,5-c]pyran (135052-87-8) → [(3aR,4S,6S,7R,7aS)-6-Methoxy-7-(4-methoxy-benzyloxy)-2,2-dimethyl-tetrahydro-[1,3]dioxolo[4,5-c]pyran-4-ylmethyl]-phosphonic acid diphenyl ester (135052-86-7)

Guidance literature:

at 140 ℃;

DOI:10.1039/c39910000667

Reference yield:

diphenyl-N,N-diethylphosphoramidite (14747-96-7) → [(3aR,4S,6S,7R,7aS)-6-Methoxy-7-(4-methoxy-benzyloxy)-2,2-dimethyl-tetrahydro-[1,3]dioxolo[4,5-c]pyran-4-ylmethyl]-phosphonic acid diphenyl ester (135052-86-7)

Guidance literature:

Multi-step reaction with 2 steps

1: tetrazole / 1,2-dimethoxy-ethane / 6 h / 20 °C

2: 70 percent / 140 °C

With 1H-tetrazole; In 1,2-dimethoxyethane;

DOI:10.1039/c39910000667

upstream raw materials:

diphenyl methyl phosphite

(3aR,4S,6S,7R,7aS)-4-Iodomethyl-6-methoxy-7-(4-methoxy-benzyloxy)-2,2-dimethyl-tetrahydro-[1,3]dioxolo[4,5-c]pyran

isopropyl diphenyl phosphite

diphenyl-N,N-diethylphosphoramidite