1-[(3'R,6'S)-1'-benzyl-3'-chloromethyl-5'-ethoxy-(6'H)-6'-isopropylpyrazin-3'-yl-2'-one]-3-[(3''R,6''S)-1''-benzyl-5''-ethoxy-3'',6''-dihydro-6''-isopropylpyrazin-3''-yl-2''-one]propane

Base Information

Chemical Name:1-[(3'R,6'S)-1'-benzyl-3'-chloromethyl-5'-ethoxy-(6'H)-6'-isopropylpyrazin-3'-yl-2'-one]-3-[(3''R,6''S)-1''-benzyl-5''-ethoxy-3'',6''-dihydro-6''-isopropylpyrazin-3''-yl-2''-one]propane
CAS No.:433735-12-7
Molecular Formula:C₃₆H₄₉ClN₄O₄
Molecular Weight:637.262
Hs Code.:

1-[(3'R,6'S)-1'-benzyl-3'-chloromethyl-5'-ethoxy-(6'H)-6'-isopropylpyrazin-3'-yl-2'-one]-3-[(3''R,6''S)-1''-benzyl-5''-ethoxy-3'',6''-dihydro-6''-isopropylpyrazin-3''-yl-2''-one]propane

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Chemical Property of 1-[(3'R,6'S)-1'-benzyl-3'-chloromethyl-5'-ethoxy-(6'H)-6'-isopropylpyrazin-3'-yl-2'-one]-3-[(3''R,6''S)-1''-benzyl-5''-ethoxy-3'',6''-dihydro-6''-isopropylpyrazin-3''-yl-2''-one]propane

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Technology Process of 1-[(3'R,6'S)-1'-benzyl-3'-chloromethyl-5'-ethoxy-(6'H)-6'-isopropylpyrazin-3'-yl-2'-one]-3-[(3''R,6''S)-1''-benzyl-5''-ethoxy-3'',6''-dihydro-6''-isopropylpyrazin-3''-yl-2''-one]propane

There total 7 articles about 1-[(3'R,6'S)-1'-benzyl-3'-chloromethyl-5'-ethoxy-(6'H)-6'-isopropylpyrazin-3'-yl-2'-one]-3-[(3''R,6''S)-1''-benzyl-5''-ethoxy-3'',6''-dihydro-6''-isopropylpyrazin-3''-yl-2''-one]propane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 593-71-5
Chloroiodomethane

: 433735-04-7
1-[(3'R,6'S)-1'-benzyl-5'-ethoxy-3',6'-dihydro-6'-isopropylpyrazin-3'-yl-2'-one]-3-[(3''R,6''S)-1''-benzyl-5''-ethoxy-3'',6''-dihydro-6''-isopropylpyrazin-3''-yl-2''-one]propane

: 433735-12-7
1-[(3'R,6'S)-1'-benzyl-3'-chloromethyl-5'-ethoxy-(6'H)-6'-isopropylpyrazin-3'-yl-2'-one]-3-[(3''R,6''S)-1''-benzyl-5''-ethoxy-3'',6''-dihydro-6''-isopropylpyrazin-3''-yl-2''-one]propane

: 1-[(3'S,6'S)-1'-benzyl-3'-chloromethyl-5'-ethoxy-(6'H)-6'-isopropylpyrazin-3'-yl-2'-one]-3-[(3''R,6''S)-1''-benzyl-5''-ethoxy-3'',6''-dihydro-6''-isopropylpyrazin-3''-yl-2''-one]propane

: C₃₇H₅₀Cl₂N₄O₄

Guidance literature:: 1-[(3'R,6'S)-1'-benzyl-5'-ethoxy-3',6'-dihydro-6'-isopropylpyrazin-3'-yl-2'-one]-3-[(3''R,6''S)-1''-benzyl-5''-ethoxy-3'',6''-dihydro-6''-isopropylpyrazin-3''-yl-2''-one]propane; With lithium hexamethyldisilazane; In tetrahydrofuran; at -78 ℃; for 1h;

Chloroiodomethane; In tetrahydrofuran; at -78 - 20 ℃;
DOI:10.1016/S0957-4166(02)00002-2

Reference yield:

: 4070-48-8
L-Valine methyl ester

: 433735-12-7
1-[(3'R,6'S)-1'-benzyl-3'-chloromethyl-5'-ethoxy-(6'H)-6'-isopropylpyrazin-3'-yl-2'-one]-3-[(3''R,6''S)-1''-benzyl-5''-ethoxy-3'',6''-dihydro-6''-isopropylpyrazin-3''-yl-2''-one]propane

Guidance literature:: Multi-step reaction with 6 steps

1.1: 85 percent / pyridine / CH₂Cl₂ / 20 °C

2.1: 96 percent / TEA / CH₂Cl₂

3.1: NH₃ / ethanol / 20 °C

4.1: 75 percent / CH₂Cl₂ / 20 °C

5.1: LHMDS / tetrahydrofuran / 1 h / -78 °C

5.2: 78 percent / tetrahydrofuran / -78 °C

6.1: LHMDS / tetrahydrofuran / 1 h / -78 °C

6.2: 90 percent Spectr_. / tetrahydrofuran / -78 - 20 °C

With pyridine; TEA; ammonia; lithium hexamethyldisilazane; In tetrahydrofuran; ethanol; dichloromethane;
DOI:10.1016/S0957-4166(02)00002-2

Reference yield:

: 100-39-0
benzyl bromide

: 433735-12-7
1-[(3'R,6'S)-1'-benzyl-3'-chloromethyl-5'-ethoxy-(6'H)-6'-isopropylpyrazin-3'-yl-2'-one]-3-[(3''R,6''S)-1''-benzyl-5''-ethoxy-3'',6''-dihydro-6''-isopropylpyrazin-3''-yl-2''-one]propane

Guidance literature:: Multi-step reaction with 6 steps

1.1: 85 percent / pyridine / CH₂Cl₂ / 20 °C

2.1: 96 percent / TEA / CH₂Cl₂

3.1: NH₃ / ethanol / 20 °C

4.1: 75 percent / CH₂Cl₂ / 20 °C

5.1: LHMDS / tetrahydrofuran / 1 h / -78 °C

5.2: 78 percent / tetrahydrofuran / -78 °C

6.1: LHMDS / tetrahydrofuran / 1 h / -78 °C

6.2: 90 percent Spectr_. / tetrahydrofuran / -78 - 20 °C

With pyridine; TEA; ammonia; lithium hexamethyldisilazane; In tetrahydrofuran; ethanol; dichloromethane;
DOI:10.1016/S0957-4166(02)00002-2