H-L-Asu(OBzl)-Aib-L-Phe-D-Pro-OH TFA salt

Base Information

• Chemical Name: H-L-Asu(OBzl)-Aib-L-Phe-D-Pro-OH TFA salt
• CAS No.: 291312-78-2
• Molecular Formula: C₂HF₃O₂*C₃₃H₄₄N₄O₇
• Molecular Weight: 722.759
• Mol file: 291312-78-2.mol

Synonyms:

Chemical Property of H-L-Asu(OBzl)-Aib-L-Phe-D-Pro-OH TFA salt

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of H-L-Asu(OBzl)-Aib-L-Phe-D-Pro-OH TFA salt

There total 8 articles about H-L-Asu(OBzl)-Aib-L-Phe-D-Pro-OH TFA salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

trifluoroacetic acid (76-05-1) + Boc-L-Asu(OBzl)-Aib-L-Phe-D-Pro-OtBu (221186-92-1) → H-L-Asu(OBzl)-Aib-L-Phe-D-Pro-OH TFA salt (291312-78-2)

Guidance literature:

at 0 ℃; for 3h;

DOI:10.1007/s00726-011-0947-6

Reference yield:

N-Cbz-L-Phe (1161-13-3) → H-L-Asu(OBzl)-Aib-L-Phe-D-Pro-OH TFA salt (291312-78-2)

Guidance literature:

Multi-step reaction with 6 steps

1: benzotriazol-1-ol; dicyclohexyl-carbodiimide / N,N-dimethyl-formamide / 12 h / 20 °C

2: palladium on activated charcoal; hydrogen / acetic acid / 12 h

3: benzotriazol-1-ol; dicyclohexyl-carbodiimide / N,N-dimethyl-formamide / 12 h / 20 °C

4: palladium on activated charcoal; hydrogen / acetic acid / 12 h

5: benzotriazol-1-ol; dicyclohexyl-carbodiimide / N,N-dimethyl-formamide / 12 h / 20 °C

6: 3 h / 0 °C

With palladium on activated charcoal; hydrogen; benzotriazol-1-ol; dicyclohexyl-carbodiimide; In acetic acid; N,N-dimethyl-formamide;

DOI:10.1007/s00726-011-0947-6

Reference yield:

L-proline t-butyl ester (2812-46-6,90071-62-8,113131-45-6) → H-L-Asu(OBzl)-Aib-L-Phe-D-Pro-OH TFA salt (291312-78-2)

Guidance literature:

Multi-step reaction with 6 steps

1: benzotriazol-1-ol; dicyclohexyl-carbodiimide / N,N-dimethyl-formamide / 12 h / 20 °C

2: palladium on activated charcoal; hydrogen / acetic acid / 12 h

3: benzotriazol-1-ol; dicyclohexyl-carbodiimide / N,N-dimethyl-formamide / 12 h / 20 °C

4: palladium on activated charcoal; hydrogen / acetic acid / 12 h

5: benzotriazol-1-ol; dicyclohexyl-carbodiimide / N,N-dimethyl-formamide / 12 h / 20 °C

6: 3 h / 0 °C

With palladium on activated charcoal; hydrogen; benzotriazol-1-ol; dicyclohexyl-carbodiimide; In acetic acid; N,N-dimethyl-formamide;

DOI:10.1007/s00726-011-0947-6

upstream raw materials:

Z-D-Pro-OtBu

N-Cbz-L-Phe

L-proline t-butyl ester

(+)-(R)-tert-butyl 1-[(S)-2-amino-3-phenylpropanoyl]pyrrolidine-2-carboxylate

Downstream raw materials:

cyclo[2-aminoisobutyryl-(S)-phenylalanyl-(R)-prolyl-(S)-2-aminosuberoyl-]

(-)-benzyl 6-[(3S,9S,14aR)-9-benzyl-6,6-dimethyl-1,4,7,10-tetraoxotetradecahydropyrrolo[1,2-a][1,4,7,10]tetraazacyclododecin-3-yl]hexanoate