2-Methyl-6-(2-phenylethenyl)pyridine

Base Information

Chemical Name:2-Methyl-6-(2-phenylethenyl)pyridine
CAS No.:6266-99-5
Molecular Formula:C₁₄H₁₃N
Molecular Weight:195.264
Hs Code.:
European Community (EC) Number:635-306-9
NSC Number:36665
UNII:4X2F5X24UK
DSSTox Substance ID:DTXSID801017353
Nikkaji Number:J1.266.022G,J3.300.837F
Wikipedia:SIB-1893
Wikidata:Q7390272
ChEMBL ID:CHEMBL88612
Mol file:6266-99-5.mol

Synonyms:(E)-2-methyl-6-(2-phenylethenyl)pyridine;SIB 1893;SIB-1893;SIB1893

Suppliers and Price of 2-Methyl-6-(2-phenylethenyl)pyridine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Usbiological
SIB 1893
10mg
$ 389.00

TRC
SIB 1893
10mg
$ 80.00

Tocris
SIB 1893
10
$ 118.00

Tocris
SIB 1893
50
$ 495.00

Sigma-Aldrich
SIB 1893 >99%, solid
10 mg
$ 120.00

ApexBio Technology
SIB 1893
10mg
$ 228.00

ApexBio Technology
SIB 1893
50mg
$ 959.00

American Custom Chemicals Corporation
SIB 1893 95.00%
1G
$ 1529.85

American Custom Chemicals Corporation
SIB 1893 95.00%
10MG
$ 653.68

Total 20 raw suppliers

Chemical Property of 2-Methyl-6-(2-phenylethenyl)pyridine

Chemical Property:

Appearance/Colour:solid
Vapor Pressure:0.00133mmHg at 25°C
Refractive Index:1.651
Boiling Point:307.3 °C at 760 mmHg
Flash Point:128.8 °C
PSA：12.89000
Density:1.072 g/cm³
LogP:3.56040
Storage Temp.:2-8°C
Solubility.:DMSO: 18 mg/mL
XLogP3:3.6
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:1
Rotatable Bond Count:2
Exact Mass:195.104799419
Heavy Atom Count:15
Complexity:203

Purity/Quality:

99% ^*data from raw suppliers

SIB 1893 ^*data from reagent suppliers

Safty Information:

Pictogram(s): Xi
Hazard Codes:Xi
Statements: 36/37/38
Safety Statements: 26-36

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1=NC(=CC=C1)C=CC2=CC=CC=C2
Isomeric SMILES:CC1=NC(=CC=C1)/C=C/C2=CC=CC=C2
Uses SIB 1893 is a selective antagonist of mGluR-5. SIB 1893 acts as a positive allosteric modulator of human metabotropic mGlu4 (1). Anticonvulsant (2).

Technology Process of 2-Methyl-6-(2-phenylethenyl)pyridine

There total 19 articles about 2-Methyl-6-(2-phenylethenyl)pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 96206-92-7
2-methyl-6-(phenylethynyl)pyridine

: 7370-21-0,6266-99-5
2-methyl-6-[(E)-2-phenylethenyl]pyridine

Guidance literature:: With sodiumsulfide nonahydrate; In N,N-dimethyl-formamide; at 140 ℃; for 10h; stereoselective reaction;
DOI:10.1021/ol501137x

Reference yield: 82.0%

: 108-48-5
2,6-dimethylpyridine

: 100-52-7
benzaldehyde

: 7370-21-0,6266-99-5
2-methyl-6-[(E)-2-phenylethenyl]pyridine

Guidance literature:: With Trifluoromethanesulfonamide; bis(trifluoromethane)sulfonimide lithium; In toluene; at 120 ℃; for 24h; Inert atmosphere; Schlenk technique;
DOI:10.1002/ejoc.201400073

Reference yield: 82.0%

: 5315-25-3
2-bromo-6-methylpyridine

: 103-64-0,1340-14-3
bromostyrene

: 7370-21-0,6266-99-5
2-methyl-6-[(E)-2-phenylethenyl]pyridine

Guidance literature:: With potassium fluoride; bis(1,5-cyclooctadiene)nickel ⁽⁰⁾; N,N-dimethyl acetamide; 4,4'-di-tert-butyl-2,2'-bipyridine; magnesium chloride; zinc; at 0 - 20 ℃; for 15h; chemoselective reaction; Schlenk technique; Sealed tube; Inert atmosphere;
DOI:10.1002/anie.201607959