(S)-N-(2-((S)-1-benzyl-3-((E)-4-(ter t-butyldimethylsilyloxy)-3-methylbut-2-enyl)-2-oxoindolin-3-yl)ethyl)-N,2-dimethylpropane-2-sulfinamide

Base Information

Chemical Name:(S)-N-(2-((S)-1-benzyl-3-((E)-4-(ter t-butyldimethylsilyloxy)-3-methylbut-2-enyl)-2-oxoindolin-3-yl)ethyl)-N,2-dimethylpropane-2-sulfinamide
CAS No.:1380585-98-7
Molecular Formula:C₃₃H₅₀N₂O₃SSi
Molecular Weight:582.923
Hs Code.:

(S)-N-(2-((S)-1-benzyl-3-((E)-4-(ter t-butyldimethylsilyloxy)-3-methylbut-2-enyl)-2-oxoindolin-3-yl)ethyl)-N,2-dimethylpropane-2-sulfinamide

Synonyms:

Suppliers and Price of (S)-N-(2-((S)-1-benzyl-3-((E)-4-(ter t-butyldimethylsilyloxy)-3-methylbut-2-enyl)-2-oxoindolin-3-yl)ethyl)-N,2-dimethylpropane-2-sulfinamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (S)-N-(2-((S)-1-benzyl-3-((E)-4-(ter t-butyldimethylsilyloxy)-3-methylbut-2-enyl)-2-oxoindolin-3-yl)ethyl)-N,2-dimethylpropane-2-sulfinamide

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (S)-N-(2-((S)-1-benzyl-3-((E)-4-(ter t-butyldimethylsilyloxy)-3-methylbut-2-enyl)-2-oxoindolin-3-yl)ethyl)-N,2-dimethylpropane-2-sulfinamide

There total 8 articles about (S)-N-(2-((S)-1-benzyl-3-((E)-4-(ter t-butyldimethylsilyloxy)-3-methylbut-2-enyl)-2-oxoindolin-3-yl)ethyl)-N,2-dimethylpropane-2-sulfinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1380585-86-3
N-benzyl-N-(2-bromophenyl)-4-hydroxybutanamide

: 1380585-98-7
(S)-N-(2-((S)-1-benzyl-3-((E)-4-(ter t-butyldimethylsilyloxy)-3-methylbut-2-enyl)-2-oxoindolin-3-yl)ethyl)-N,2-dimethylpropane-2-sulfinamide

: (S)-N-(2-((R)-1-benzyl-3-((E)-4-(ter t-butyldimethylsilyloxy)-3-methylbut-2-enyl)-2-oxoindolin-3-yl)ethyl)-N,2-dimethylpropane-2-sulfinamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: Dess-Martin periodane / dichloromethane / 6 h / 20 °C / Inert atmosphere

2.1: potassium hydrogensulfate / toluene / 3 h / 45 °C / Inert atmosphere

3.1: sodium tetrahydroborate / methanol / 4.5 h / 0 °C / Inert atmosphere

4.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / 0 °C / Inert atmosphere

4.2: 15 h / 20 °C / Inert atmosphere

5.1: copper(l) iodide; lithium hexamethyldisilazane / tetrahydrofuran / 75 - 80 °C / Inert atmosphere

6.1: tetrahydrofuran / 15 h / 0 - 20 °C / Inert atmosphere

With sodium tetrahydroborate; potassium hydrogensulfate; copper(l) iodide; sodium hydride; Dess-Martin periodane; lithium hexamethyldisilazane; In tetrahydrofuran; methanol; dichloromethane; toluene; mineral oil;
DOI:10.1021/ol3012056

Reference yield:

: 1380585-87-4
N-benzyl-N-(2-bromophenyl)-4-oxobutanamide

: 1380585-98-7
(S)-N-(2-((S)-1-benzyl-3-((E)-4-(ter t-butyldimethylsilyloxy)-3-methylbut-2-enyl)-2-oxoindolin-3-yl)ethyl)-N,2-dimethylpropane-2-sulfinamide

: (S)-N-(2-((R)-1-benzyl-3-((E)-4-(ter t-butyldimethylsilyloxy)-3-methylbut-2-enyl)-2-oxoindolin-3-yl)ethyl)-N,2-dimethylpropane-2-sulfinamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium hydrogensulfate / toluene / 3 h / 45 °C / Inert atmosphere

2.1: sodium tetrahydroborate / methanol / 4.5 h / 0 °C / Inert atmosphere

3.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / 0 °C / Inert atmosphere

3.2: 15 h / 20 °C / Inert atmosphere

4.1: copper(l) iodide; lithium hexamethyldisilazane / tetrahydrofuran / 75 - 80 °C / Inert atmosphere

5.1: tetrahydrofuran / 15 h / 0 - 20 °C / Inert atmosphere

With sodium tetrahydroborate; potassium hydrogensulfate; copper(l) iodide; sodium hydride; lithium hexamethyldisilazane; In tetrahydrofuran; methanol; toluene; mineral oil;
DOI:10.1021/ol3012056

Reference yield:

: 615-36-1
2-bromoaniline

: 1380585-98-7
(S)-N-(2-((S)-1-benzyl-3-((E)-4-(ter t-butyldimethylsilyloxy)-3-methylbut-2-enyl)-2-oxoindolin-3-yl)ethyl)-N,2-dimethylpropane-2-sulfinamide

: (S)-N-(2-((R)-1-benzyl-3-((E)-4-(ter t-butyldimethylsilyloxy)-3-methylbut-2-enyl)-2-oxoindolin-3-yl)ethyl)-N,2-dimethylpropane-2-sulfinamide

Guidance literature:: Multi-step reaction with 8 steps

1.1: trimethylaluminum / toluene / 0.75 h / 0 - 20 °C / Inert atmosphere

1.2: 20 °C / Inert atmosphere

2.1: caesium carbonate / N,N-dimethyl-formamide; acetonitrile / 8 h / 0 - 20 °C / Inert atmosphere

3.1: Dess-Martin periodane / dichloromethane / 6 h / 20 °C / Inert atmosphere

4.1: potassium hydrogensulfate / toluene / 3 h / 45 °C / Inert atmosphere

5.1: sodium tetrahydroborate / methanol / 4.5 h / 0 °C / Inert atmosphere

6.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / 0 °C / Inert atmosphere

6.2: 15 h / 20 °C / Inert atmosphere

7.1: copper(l) iodide; lithium hexamethyldisilazane / tetrahydrofuran / 75 - 80 °C / Inert atmosphere

8.1: tetrahydrofuran / 15 h / 0 - 20 °C / Inert atmosphere

With sodium tetrahydroborate; potassium hydrogensulfate; copper(l) iodide; trimethylaluminum; sodium hydride; caesium carbonate; Dess-Martin periodane; lithium hexamethyldisilazane; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; toluene; acetonitrile; mineral oil;
DOI:10.1021/ol3012056