trans-indane-1,2-diol

Base Information

• Chemical Name: trans-indane-1,2-diol
• CAS No.: 67528-22-7
• Molecular Formula: C₉H₁₀O₂
• Molecular Weight: 150.177
• Mol file: 67528-22-7.mol

Synonyms:

Chemical Property of trans-indane-1,2-diol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of trans-indane-1,2-diol

There total 133 articles about trans-indane-1,2-diol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

trans-2-bromo-1-indanol (10368-44-2,78684-69-2) + acetic anhydride (108-24-7) → cis-indane-1,2-diol (4370-02-9,4647-42-1,4647-43-2,67528-22-7,67528-23-8,71214-80-7,71214-82-9,78737-68-5)

Guidance literature:

trans-2-bromo-1-indanol; acetic anhydride; at 65 ℃; for 5h;

With sodium hydroxide; In water;

DOI:10.1016/S0957-4166(01)00006-4

Reference yield: 88.0%

cis-1,2-dihydroxyindane carbonate (19597-98-9,67131-50-4) → cis-indane-1,2-diol (4370-02-9,4647-42-1,4647-43-2,67528-22-7,67528-23-8,71214-80-7,71214-82-9,78737-68-5)

Guidance literature:

With water; sodium hydroxide; In methanol; at 20 ℃;

DOI:10.1002/anie.201406645

Reference yield: 87.0%

1-indene (95-13-6) → cis-indane-1,2-diol (4370-02-9,4647-42-1,4647-43-2,67528-22-7,67528-23-8,71214-80-7,71214-82-9,78737-68-5)

Guidance literature:

1-indene; With sodium periodate; acetic acid; lithium bromide; at 95 ℃; for 18h;

With potassium carbonate; In methanol; at 25 ℃; for 24h;

DOI:10.1021/ol052080n

upstream raw materials:

1-indene

cis-indane-1,2-diol

indan-2-ol

(1R,2S)-1,2-diacetoxyindane

Downstream raw materials:

(3aR,8aS)-2-Methyl-8,8a-dihydro-3aH-indeno[1,2-d]oxazole

(1R,2S)-1-Amino-2-indanol

2-indanone

(3aS,3a'S,8aR,8a'R)-2,2'-(propane-2,2-diyl)bis(3a,8a-dihydro-8H-indeno[1,2-d]oxazole)