Technology Process of methyl 4-[2,2-difluoro-2-(2-phenylcyclohex-2-en-1-yl)ethyl]-benzoate
There total 7 articles about methyl 4-[2,2-difluoro-2-(2-phenylcyclohex-2-en-1-yl)ethyl]-benzoate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
copper(l) iodide; 1,10-Phenanthroline;
In
N,N-dimethyl-formamide; acetonitrile;
at -25 ℃;
for 2h;
Schlenk technique;
Inert atmosphere;
DOI:10.1021/jo4024705
- Guidance literature:
-
Multi-step reaction with 5 steps
1: tetrahydrofuran / 1 h / -30 - 20 °C / Schlenk technique; Inert atmosphere
2: toluene-4-sulfonic acid / toluene / 1 h / Schlenk technique; Inert atmosphere; Dean-Stark; Reflux
3: water; N-Bromosuccinimide / acetone / 3 h / 10 °C / Schlenk technique; Inert atmosphere
4: sulfuric acid; acetic acid / hexane / 0.08 h / Schlenk technique; Inert atmosphere
5: 1,10-Phenanthroline; copper(l) iodide / acetonitrile; N,N-dimethyl-formamide / 2 h / -25 °C / Schlenk technique; Inert atmosphere
With
N-Bromosuccinimide; copper(l) iodide; 1,10-Phenanthroline; sulfuric acid; water; toluene-4-sulfonic acid; acetic acid;
In
tetrahydrofuran; hexane; N,N-dimethyl-formamide; acetone; toluene; acetonitrile;
DOI:10.1021/jo4024705
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: sodium acetate / acetonitrile / 0.17 h / -25 - 20 °C / Schlenk technique; Inert atmosphere
1.2: 18 h / -25 °C / Schlenk technique; Inert atmosphere
2.1: 1,10-Phenanthroline; copper(l) iodide / acetonitrile; N,N-dimethyl-formamide / 2 h / -25 °C / Schlenk technique; Inert atmosphere
With
copper(l) iodide; 1,10-Phenanthroline; sodium acetate;
In
N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jo4024705