benzhydryl 2-<(4S)-4--3-oxo-2-isoxazolidinyl>-5-oxo-2-tetrahydrofurancarboxylate

Base Information

• Chemical Name: benzhydryl 2-<(4S)-4--3-oxo-2-isoxazolidinyl>-5-oxo-2-tetrahydrofurancarboxylate
• CAS No.: 106962-51-0
• Molecular Formula: C₂₃H₂₁ClN₂O₇
• Molecular Weight: 472.882

Synonyms:

Chemical Property of benzhydryl 2-<(4S)-4--3-oxo-2-isoxazolidinyl>-5-oxo-2-tetrahydrofurancarboxylate

Chemical Property:

Purity/Quality:

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Technology Process of benzhydryl 2-<(4S)-4--3-oxo-2-isoxazolidinyl>-5-oxo-2-tetrahydrofurancarboxylate

There total 1 articles about benzhydryl 2-<(4S)-4--3-oxo-2-isoxazolidinyl>-5-oxo-2-tetrahydrofurancarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

benzhydryl 2-<(4S)-4-amino-3-oxo-2-isoxazolidinyl>-5-oxo-2-tetrahydrofurancarboxylate (106962-17-8,106962-18-9,115441-24-2) + chloroacetyl chloride (79-04-9) → benzhydryl 2-<(4S)-4--3-oxo-2-isoxazolidinyl>-5-oxo-2-tetrahydrofurancarboxylate (106962-51-0,106963-62-6,128811-83-6)

Guidance literature:

With 2,4-dichlorophenoxyacetic acid dimethylamine; In dichloromethane; 0 deg C, 10 min, room temp., 20 min;

DOI:10.1248/cpb.38.116

Reference yield: 70.0%

pyridine-4-thiol (4556-23-4) + benzhydryl 2-<(4S)-4--3-oxo-2-isoxazolidinyl>-5-oxo-2-tetrahydrofurancarboxylate (106962-51-0,106963-62-6,128811-83-6) → 5-Oxo-2-{(S)-3-oxo-4-[2-(pyridin-4-ylsulfanyl)-acetylamino]-isoxazolidin-2-yl}-tetrahydro-furan-2-carboxylic acid benzhydryl ester (106962-53-2,106963-64-8,128797-40-0)

Guidance literature:

With sodium hydride; sodium iodide; In N,N-dimethyl-formamide; for 0.5h; Ambient temperature;

DOI:10.1248/cpb.38.116

Reference yield: 46.0%

2-Chloro-pyridine-4-thiol (106962-88-3) + benzhydryl 2-<(4S)-4--3-oxo-2-isoxazolidinyl>-5-oxo-2-tetrahydrofurancarboxylate (106962-51-0,106963-62-6,128811-83-6) → benzhydryl 2-<(4S)-4-<(2-chloro-4-pyridylthio)acetylamino>-3-oxo-2-isoxazolidinyl>-5-oxo-2-tetrahydrofurancarboxylate (106962-89-4,106964-21-0,128797-41-1)

Guidance literature:

With sodium hydride; sodium iodide; In N,N-dimethyl-formamide; for 0.5h; Ambient temperature;

DOI:10.1248/cpb.38.116

upstream raw materials:

benzhydryl 2-<(4S)-4-amino-3-oxo-2-isoxazolidinyl>-5-oxo-2-tetrahydrofurancarboxylate

chloroacetyl chloride

Downstream raw materials:

5-Oxo-2-{(S)-3-oxo-4-[2-(pyridin-4-ylsulfanyl)-acetylamino]-isoxazolidin-2-yl}-tetrahydro-furan-2-carboxylic acid benzhydryl ester

benzhydryl 2-<(4S)-4-<(2-chloro-4-pyridylthio)acetylamino>-3-oxo-2-isoxazolidinyl>-5-oxo-2-tetrahydrofurancarboxylate

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