GSK481

Base Information

Chemical Name:GSK481
CAS No.:1622849-58-4
Molecular Formula:C₂₁H₁₉N₃O₄
Molecular Weight:377.4
Hs Code.:
Mol file:1622849-58-4.mol

Synonyms:

Suppliers and Price of GSK481

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Sigma-Aldrich
GSK′481 ≥98% (HPLC)
5MG
$ 155.00

Sigma-Aldrich
GSK′481 ≥98% (HPLC)
25MG
$ 621.00

DC Chemicals
GSK481
250mg
$ 1340.00

DC Chemicals
GSK481
100 mg
$ 670.00

Crysdot
GSK'481 98+%
100mg
$ 832.00

Crysdot
GSK'481 98+%
50mg
$ 520.00

Crysdot
GSK'481 98+%
5mg
$ 97.00

Crysdot
GSK'481 98+%
10mg
$ 153.00

Cayman Chemical
GSK481 ≥98%
10mg
$ 200.00

Cayman Chemical
GSK481 ≥98%
1mg
$ 25.00

Total 11 raw suppliers

Chemical Property of GSK481

Chemical Property:

Boiling Point:677.0±55.0 °C(Predicted)
PKA:11.68±0.20(Predicted)
Density:1.35±0.1 g/cm3(Predicted)
Solubility.:Soluble in DMSO

Purity/Quality:

99%, ^*data from raw suppliers

GSK′481 ≥98% (HPLC) ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of GSK481

There total 6 articles about GSK481 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 99197-78-1
(S)-2-((tert-butoxycarbonyl)amino)-3-(2-nitrophenoxy)propanoic acid

: 1622849-58-4
(S)-5-benzyl-N-(5-methyl-4-oxo-2,3,4,5-tetrahydrobenzo[b]-[1,4]oxazepin-3-yl)isoxazole-3-carboxamide

Guidance literature:: Multi-step reaction with 5 steps

1: hydrogen; palladium on activated charcoal / methanol / 20 °C

2: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / dimethyl sulfoxide / 20 °C

3: caesium carbonate / N,N-dimethyl-formamide

4: hydrogenchloride

5: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide

With hydrogenchloride; palladium on activated charcoal; hydrogen; caesium carbonate; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In methanol; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1021/acsmedchemlett.9b00108

Reference yield:

: 99197-80-5
(S)-tert-butyl (4-oxo-2,3,4,5-tetrahydrobenzo[b][1,4]oxazepine-3-yl)aminoformate

: 1622849-58-4
(S)-5-benzyl-N-(5-methyl-4-oxo-2,3,4,5-tetrahydrobenzo[b]-[1,4]oxazepin-3-yl)isoxazole-3-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1: caesium carbonate / N,N-dimethyl-formamide

2: hydrogenchloride

3: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide

With hydrogenchloride; caesium carbonate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide;
DOI:10.1021/acsmedchemlett.9b00108

Reference yield:

: 99197-79-2
2(S)-3-(2-aminophenoxy)-2-((tert-butoxycarbonyl)amino)propanoic acid

: 1622849-58-4
(S)-5-benzyl-N-(5-methyl-4-oxo-2,3,4,5-tetrahydrobenzo[b]-[1,4]oxazepin-3-yl)isoxazole-3-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / dimethyl sulfoxide / 20 °C

2: caesium carbonate / N,N-dimethyl-formamide

3: hydrogenchloride

4: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide

With hydrogenchloride; caesium carbonate; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1021/acsmedchemlett.9b00108