6-bromo-1-methylisoquinoline

Base Information

• Chemical Name: 6-bromo-1-methylisoquinoline
• CAS No.: 1416712-98-5
• Molecular Formula: C₁₀H₈BrN
• Molecular Weight: 222.084
• Hs Code.: 2933499090
• Mol file: 1416712-98-5.mol

Synonyms:

Chemical Property of 6-bromo-1-methylisoquinoline

Chemical Property:

• Boiling Point: 315.6±22.0 °C(Predicted)
• PKA: 5?+-.0.38(Predicted)
• Density: 1.488±0.06 g/cm3(Predicted)

Purity/Quality:

98.5% ^*data from raw suppliers

6-Bromo-1-methylisoquinoline ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 6-bromo-1-methylisoquinoline

There total 10 articles about 6-bromo-1-methylisoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

methylmagnesium chloride (676-58-4) + 6-bromo-1-chloroisoquinoline (205055-63-6) → 6-bromo-1-methylisoquinoline (1416712-98-5)

Guidance literature:

With iron(III)-acetylacetonate; N,N,N,N,-tetramethylethylenediamine; In tetrahydrofuran; 2-methyltetrahydrofuran; at 0 - 2 ℃; for 3.5h;

Reference yield: 72.0%

vinyl acetate (108-05-4,9003-20-7) + (E)-1-(4-bromophenyl) ethanone O-acetyl oxime → 6-bromo-1-methylisoquinoline (1416712-98-5)

Guidance literature:

With dichloro(pentamethylcyclopentadienyl)rhodium (III) dimer; cesium acetate; In methanol; at 60 ℃; for 48h; Inert atmosphere; Sealed tube;

DOI:10.1016/j.tet.2018.05.063

Reference yield: 39.0%

vinyl acetate (108-05-4,9003-20-7) + 1-(4-bromophenyl)ethanone O-acetyl oxime (299456-72-7) → 6-bromo-1-methylisoquinoline (1416712-98-5)

Guidance literature:

With dichloro(pentamethylcyclopentadienyl)rhodium (III) dimer; silver(I) acetate; In methanol; at 100 ℃; for 12h;

DOI:10.1039/c5cc04708k

upstream raw materials:

vinyl acetate

1-(4-bromophenyl)ethanone O-acetyl oxime

methylmagnesium chloride

6-bromo-1-chloroisoquinoline

Downstream raw materials:

1-methylisoquinolin-6-amine