Technology Process of 5-(4-chlorophenyl)-4-(3-iodophenyl)-1,2-dimethyl-N-(3-(4-methylpiperazin-1-yl)propyl)-1H-pyrrole-3-carboxamide
There total 5 articles about 5-(4-chlorophenyl)-4-(3-iodophenyl)-1,2-dimethyl-N-(3-(4-methylpiperazin-1-yl)propyl)-1H-pyrrole-3-carboxamide which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 3 steps
1: methanol / Inert atmosphere
2: sodium hydroxide / 1,4-dioxane; ethanol; water / Reflux; Inert atmosphere
3: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / dichloromethane / 8 h / Inert atmosphere
With
benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; sodium hydroxide;
In
1,4-dioxane; methanol; ethanol; dichloromethane; water;
1: Paal-Knorr pyrrole synthesis;
DOI:10.1021/jm300608w
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 3-ethyl-5-(2-hydroxyethyl)-4-methyl-1,3-thiazolium bromide; triethylamine / 70 °C / Inert atmosphere
2: acetic acid / methanol / 24 h / 65 °C / Inert atmosphere; Sealed tube
3: sodium hydroxide / 1,4-dioxane; ethanol; water / Reflux; Inert atmosphere
4: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / dichloromethane / 8 h / Inert atmosphere
With
3-ethyl-5-(2-hydroxyethyl)-4-methyl-1,3-thiazolium bromide; benzotriazol-1-ol; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; sodium hydroxide;
In
1,4-dioxane; methanol; ethanol; dichloromethane; water;
2: Paal-Knorr pyrrole synthesis;
DOI:10.1021/jm300608w
- Guidance literature:
-
Multi-step reaction with 5 steps
1: piperidine; acetic acid / toluene / Inert atmosphere; Reflux
2: 3-ethyl-5-(2-hydroxyethyl)-4-methyl-1,3-thiazolium bromide; triethylamine / 70 °C / Inert atmosphere
3: methanol / Inert atmosphere
4: sodium hydroxide / 1,4-dioxane; ethanol; water / Reflux; Inert atmosphere
5: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / dichloromethane / 8 h / Inert atmosphere
With
piperidine; 3-ethyl-5-(2-hydroxyethyl)-4-methyl-1,3-thiazolium bromide; benzotriazol-1-ol; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; sodium hydroxide;
In
1,4-dioxane; methanol; ethanol; dichloromethane; water; toluene;
3: Paal-Knorr pyrrole synthesis;
DOI:10.1021/jm300608w
