(2S,3S,4S)-3,4-Bis-benzyloxy-2-[(1S,2R)-1-benzyloxy-2-((2R,3S,4R,5S)-4-benzyloxy-5-bromomethyl-3,5-dimethyl-tetrahydro-furan-2-yl)-3-methoxymethoxy-propyl]-5-hydroxy-4-methyl-pentanoic acid methoxy-methyl-amide

Base Information

• Chemical Name: (2S,3S,4S)-3,4-Bis-benzyloxy-2-[(1S,2R)-1-benzyloxy-2-((2R,3S,4R,5S)-4-benzyloxy-5-bromomethyl-3,5-dimethyl-tetrahydro-furan-2-yl)-3-methoxymethoxy-propyl]-5-hydroxy-4-methyl-pentanoic acid methoxy-methyl-amide
• CAS No.: 129189-24-8
• Molecular Formula: C₄₈H₆₂BrNO₁₀
• Molecular Weight: 892.925

Synonyms:

Chemical Property of (2S,3S,4S)-3,4-Bis-benzyloxy-2-[(1S,2R)-1-benzyloxy-2-((2R,3S,4R,5S)-4-benzyloxy-5-bromomethyl-3,5-dimethyl-tetrahydro-furan-2-yl)-3-methoxymethoxy-propyl]-5-hydroxy-4-methyl-pentanoic acid methoxy-methyl-amide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2S,3S,4S)-3,4-Bis-benzyloxy-2-[(1S,2R)-1-benzyloxy-2-((2R,3S,4R,5S)-4-benzyloxy-5-bromomethyl-3,5-dimethyl-tetrahydro-furan-2-yl)-3-methoxymethoxy-propyl]-5-hydroxy-4-methyl-pentanoic acid methoxy-methyl-amide

There total 1 articles about (2S,3S,4S)-3,4-Bis-benzyloxy-2-[(1S,2R)-1-benzyloxy-2-((2R,3S,4R,5S)-4-benzyloxy-5-bromomethyl-3,5-dimethyl-tetrahydro-furan-2-yl)-3-methoxymethoxy-propyl]-5-hydroxy-4-methyl-pentanoic acid methoxy-methyl-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

C46H55BrO9 (128041-97-4) → (2S,3S,4S)-3,4-Bis-benzyloxy-2-[(1S,2R)-1-benzyloxy-2-((2R,3S,4R,5S)-4-benzyloxy-5-bromomethyl-3,5-dimethyl-tetrahydro-furan-2-yl)-3-methoxymethoxy-propyl]-5-hydroxy-4-methyl-pentanoic acid methoxy-methyl-amide (129189-24-8)

Guidance literature:

In dichloromethane; for 16h; Ambient temperature;

DOI:10.1016/S0040-4020(01)97592-1

Reference yield:

(2S,3S,4S)-3,4-Bis-benzyloxy-2-[(1S,2R)-1-benzyloxy-2-((2R,3S,4R,5S)-4-benzyloxy-5-bromomethyl-3,5-dimethyl-tetrahydro-furan-2-yl)-3-methoxymethoxy-propyl]-5-hydroxy-4-methyl-pentanoic acid methoxy-methyl-amide (129189-24-8) → (S)-4-[(1S,2S,3R,4R)-1,3-Bis-benzyloxy-4-((2R,3S,4R,5S)-4-benzyloxy-5-bromomethyl-3,5-dimethyl-tetrahydro-furan-2-yl)-5-methoxymethoxy-2-methyl-pentyl]-4-methyl-[1,3]dioxolan-2-one (129163-52-6)

Guidance literature:

Multi-step reaction with 10 steps

1: pyridinium p-toluenesulfonate / CH₂Cl₂ / 7 h / Ambient temperature

2: lithium aluminum hydride / diethyl ether / 0.5 h / Ambient temperature

3: 1.) n-butyllithium / 1.) tetrahydrofuran, room temperature, 20 min, 2.) -78 deg C --> room temperature

4: 1.) iodine, sodium bicarbonate, 2.) conc. hydrochloric acid / 1.) acetonitrile, 0 deg C, 10 min, 2.) tetrahydrofuran, 20 min, room temperature

5: 80 percent / amalgamated zinc / ethanol / 1 h / Heating

6: pyridine / toluene; CH₂Cl₂ / 1.) 0 deg C --> room temperature, 2.) 10 min, rt

7: 1.) ozone, 2.) dimethylsulfide / 1.) methanol, dichloromethane, -78 deg C, 10 min, 2.) 0 deg C, 1 h

8: sodium borohydride / ethanol / 0.17 h / 0 °C

9: 80 percent / triphenylphosphine, iodine, imidazole / benzene / 0.5 h / Ambient temperature

10: amalgamated zinc, ammoniumchloride / ethanol / 0.5 h / Heating

With pyridine; 1H-imidazole; hydrogenchloride; sodium tetrahydroborate; lithium aluminium tetrahydride; n-butyllithium; amalgamated zinc; dimethylsulfide; ammonium chloride; iodine; pyridinium p-toluenesulfonate; sodium hydrogencarbonate; ozone; triphenylphosphine; In diethyl ether; ethanol; dichloromethane; toluene; benzene;

DOI:10.1016/S0040-4020(01)97592-1

Reference yield:

(2S,3S,4S)-3,4-Bis-benzyloxy-2-[(1S,2R)-1-benzyloxy-2-((2R,3S,4R,5S)-4-benzyloxy-5-bromomethyl-3,5-dimethyl-tetrahydro-furan-2-yl)-3-methoxymethoxy-propyl]-5-hydroxy-4-methyl-pentanoic acid methoxy-methyl-amide (129189-24-8) → (3R,4S,5R,6S,7R,8S,9S)-3,7,9-Tris-benzyloxy-6-methoxymethoxymethyl-2,4,8-trimethyl-9-((S)-2,2,4-trimethyl-[1,3]dioxolan-4-yl)-non-1-en-5-ol (123506-10-5)

Guidance literature:

Multi-step reaction with 11 steps

1: pyridinium p-toluenesulfonate / CH₂Cl₂ / 7 h / Ambient temperature

2: lithium aluminum hydride / diethyl ether / 0.5 h / Ambient temperature

3: 1.) n-butyllithium / 1.) tetrahydrofuran, room temperature, 20 min, 2.) -78 deg C --> room temperature

4: 1.) iodine, sodium bicarbonate, 2.) conc. hydrochloric acid / 1.) acetonitrile, 0 deg C, 10 min, 2.) tetrahydrofuran, 20 min, room temperature

5: 80 percent / amalgamated zinc / ethanol / 1 h / Heating

6: pyridine / toluene; CH₂Cl₂ / 1.) 0 deg C --> room temperature, 2.) 10 min, rt

7: 1.) ozone, 2.) dimethylsulfide / 1.) methanol, dichloromethane, -78 deg C, 10 min, 2.) 0 deg C, 1 h

8: sodium borohydride / ethanol / 0.17 h / 0 °C

9: 80 percent / triphenylphosphine, iodine, imidazole / benzene / 0.5 h / Ambient temperature

10: 92 percent / amalgamated zinc, ammoniumchloride / ethanol / 20 h / Heating

11: 1.) methyllithium, 2.) dicamphorsulfonic acid / 1.) ether, -78 deg C --> -20 deg C, 2.) dichloromethane, room temperature, 20 min

With pyridine; 1H-imidazole; hydrogenchloride; sodium tetrahydroborate; lithium aluminium tetrahydride; n-butyllithium; amalgamated zinc; dimethylsulfide; dicamphorsulfonic acid; ammonium chloride; methyllithium; iodine; pyridinium p-toluenesulfonate; sodium hydrogencarbonate; ozone; triphenylphosphine; In diethyl ether; ethanol; dichloromethane; toluene; benzene;

DOI:10.1016/S0040-4020(01)97592-1

upstream raw materials:

C₄₆H₅₅BrO₉

Downstream raw materials:

(3R,4S,5R,6S,7R,8S,9S)-3,7,9-Tris-benzyloxy-6-methoxymethoxymethyl-2,4,8-trimethyl-9-((S)-2,2,4-trimethyl-[1,3]dioxolan-4-yl)-non-1-en-5-ol

tri-O-benzyl-4,6,8,11,12-pentadeoxy-1,2-O-isopropylidene-6-C-(1''-methoxymethoxymethyl)-2,4,8,10-tetra-C-methyl-D-glycero-L-allo-D-gulo-11-eno-dodecitol

Tri-O-benzyl-1,2-O-carbonyl-4,6,8,10,11-pentadeoxy-6-(1''-methoxymethoxymethyl)-2,4,8,10-tetra-C-methyl-L-altro-L-galacto-10-eno-undecitol

(2S,3S,4S,5R,6R)-3,5-Bis-benzyloxy-6-((2R,3S,4R,5S)-4-benzyloxy-5-bromomethyl-3,5-dimethyl-tetrahydro-furan-2-yl)-7-methoxymethoxy-2-methyl-4-vinyl-heptane-1,2-diol

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 129189-24-8 (2S,3S,4S)-3,4-Bis-benzyloxy-2-[(1S,2R)-1-benzyloxy-2-((2R,3S,4R,5S)-4-benzyloxy-5-bromomethyl-3,5-dimethyl-tetrahydro-furan-2-yl)-3-methoxymethoxy-propyl]-5-hydroxy-4-methyl-pentanoic acid methoxy-methyl-amide

Send

Send

Metric Ton KG G Pound L ML

Send

Send