Technology Process of C23H28N2O4
There total 3 articles about C23H28N2O4 which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
(2S)-2-{diphenyl[(trimethylsilyl)oxy]methyl}pyrrolidine; acetic acid;
In
ethanol;
at 25 ℃;
for 32h;
optical yield given as %ee;
enantioselective reaction;
Inert atmosphere;
DOI:10.1021/ol200006e
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 3-benzyl-5-(2-hydroxyethyl)-4-methyl-1,3-thiazol-3-ium chloride; caesium carbonate / N,N-dimethyl-formamide / 0.5 h / 25 °C / Inert atmosphere
2: (2S)-2-{diphenyl[(trimethylsilyl)oxy]methyl}pyrrolidine; acetic acid / ethanol / 32 h / 25 °C / Inert atmosphere
With
(2S)-2-{diphenyl[(trimethylsilyl)oxy]methyl}pyrrolidine; 3-benzyl-5-(2-hydroxyethyl)-4-methyl-1,3-thiazol-3-ium chloride; caesium carbonate; acetic acid;
In
ethanol; N,N-dimethyl-formamide;
1: Stetter reaction / 2: Michael-aldol reaction;
DOI:10.1021/ol200006e
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 3-benzyl-5-(2-hydroxyethyl)-4-methyl-1,3-thiazol-3-ium chloride; caesium carbonate / N,N-dimethyl-formamide / 0.5 h / 25 °C / Inert atmosphere
2: (2S)-2-{diphenyl[(trimethylsilyl)oxy]methyl}pyrrolidine; acetic acid / ethanol / 32 h / 25 °C / Inert atmosphere
With
(2S)-2-{diphenyl[(trimethylsilyl)oxy]methyl}pyrrolidine; 3-benzyl-5-(2-hydroxyethyl)-4-methyl-1,3-thiazol-3-ium chloride; caesium carbonate; acetic acid;
In
ethanol; N,N-dimethyl-formamide;
1: Stetter reaction / 2: Michael-aldol reaction;
DOI:10.1021/ol200006e
