Technology Process of 1,4-diethyl 2-(3-chlorophenyl)butanedioate
There total 4 articles about 1,4-diethyl 2-(3-chlorophenyl)butanedioate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
2-mesityl-6,7-dihydro-5H-pyrrolo[2,1-c][1,2,4]triazol-2-ium tetrafluoroborate; N-ethyl-N,N-diisopropylamine;
In
water; 1,2-dichloro-ethane;
at 0 ℃;
for 48h;
Inert atmosphere;
DOI:10.1021/jacs.5b02887
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: magnesium / N,N-dimethyl-formamide / -15 °C
1.2: 1 h / -15 °C
1.3: 36 h / Reflux
2.1: sulfuric acid / 5 h / Reflux
With
sulfuric acid; magnesium;
In
N,N-dimethyl-formamide;
DOI:10.1246/cl.2011.368
- Guidance literature:
-
Multi-step reaction with 3 steps
1: potassium carbonate; tetrakis(triphenylphosphine) palladium(0) / toluene / 18 h / Inert atmosphere; Reflux
2: trifluoroacetic acid / tetrahydrofuran; water / 2 h / 23 °C
3: 2-mesityl-6,7-dihydro-5H-pyrrolo[2,1-c][1,2,4]triazol-2-ium tetrafluoroborate; N-ethyl-N,N-diisopropylamine / water; 1,2-dichloro-ethane / 48 h / 0 °C / Inert atmosphere
With
tetrakis(triphenylphosphine) palladium(0); 2-mesityl-6,7-dihydro-5H-pyrrolo[2,1-c][1,2,4]triazol-2-ium tetrafluoroborate; potassium carbonate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid;
In
tetrahydrofuran; water; 1,2-dichloro-ethane; toluene;
DOI:10.1021/jacs.5b02887
