E6446 (dihydrochloride)

Base Information

Chemical Name:E6446 (dihydrochloride)
CAS No.:1345675-25-3
Molecular Formula:C₂₇H₃₅N₃O₃*2ClH
Molecular Weight:522.515
Hs Code.:
Mol file:1345675-25-3.mol

Synonyms:

Suppliers and Price of E6446 (dihydrochloride)

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

DC Chemicals
E6446dihydrochloride >98%
1 g
$ 1900.00

DC Chemicals
E6446dihydrochloride >98%
100 mg
$ 550.00

CSNpharm
E-64462HCl
2mg
$ 180.00

Crysdot
E6446dihydrochloride 98+%
5mg
$ 362.00

Crysdot
E6446dihydrochloride 98+%
50mg
$ 2072.00

Crysdot
E6446dihydrochloride 98+%
10mg
$ 673.00

Chemenu
E6446dihydrochloride 98%
50mg
$ 1309.00

Arctom
E-6446Dihydrochloride 98%
5mg
$ 263.00

Arctom
E-6446Dihydrochloride 98%
2mg
$ 176.00

Ambeed
E-6446Dihydrochloride 98%
10mg
$ 346.00

Total 9 raw suppliers

Chemical Property of E6446 (dihydrochloride)

Chemical Property:

Storage Temp.:under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

99%, ^*data from raw suppliers

E6446dihydrochloride >98% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Uses E6446 is a synthetic antagonist of nucleic acid-sensing TLRs. , In vitro, low doses of E6446 specifically inhibited the activation of human and mouse TLR9. Tenfold higher concentrations of E6446 (dihydrochloride) also inhibited the human TLR8 response to single-stranded RNA. In vivo, therapy with E6446 diminished the activation of TLR9 and prevented the exacerbated cytokine response observed during acute Plasmodium infection. Furthermore, severe signs of ECM, such as limb paralysis, brain vascular leak, and death, were all prevented by oral treatment with E6446.

Technology Process of E6446 (dihydrochloride)

There total 3 articles about E6446 (dihydrochloride) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 1219925-75-3
6-(3-chloropropoxy)-2-(4-(3-chloropropoxy)phenyl)benzo[d]oxazole

: 1345675-25-3
C₂₇H₃₅N₃O₃*2ClH

Guidance literature:: With pyrrolidine; at 100 ℃; for 12h; Sealed tube;

Reference yield: 68.0%

: 123-75-1
pyrrolidine

: 1219925-75-3
6-(3-chloropropoxy)-2-(4-(3-chloropropoxy)phenyl)benzo[d]oxazole

: 1345675-25-3
C₂₇H₃₅N₃O₃*2ClH

Guidance literature:: In ethanol; at 100 ℃; for 12h; Sealed tube;

Reference yield:

: 2-(4-hydroxyphenyl)benzo[d]oxazol-6-ol

: 1345675-25-3
C₂₇H₃₅N₃O₃*2ClH

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate / dimethyl sulfoxide / 4 h / 20 °C

2: ethanol / 12 h / 100 °C / Sealed tube

With potassium carbonate; In ethanol; dimethyl sulfoxide;