2-[6-(tert-butyl-dimethyl-silanyloxy)-benzo[1,3]dioxol-5-yl]-N-diphenylphosphinoyl-amino-propionic acid ethyl ester

Base Information

• Chemical Name: 2-[6-(tert-butyl-dimethyl-silanyloxy)-benzo[1,3]dioxol-5-yl]-N-diphenylphosphinoyl-amino-propionic acid ethyl ester
• CAS No.: 1258950-79-6
• Molecular Formula: C₃₀H₃₈NO₆PSi
• Molecular Weight: 567.694
• Mol file: 1258950-79-6.mol

Synonyms:

Chemical Property of 2-[6-(tert-butyl-dimethyl-silanyloxy)-benzo[1,3]dioxol-5-yl]-N-diphenylphosphinoyl-amino-propionic acid ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-[6-(tert-butyl-dimethyl-silanyloxy)-benzo[1,3]dioxol-5-yl]-N-diphenylphosphinoyl-amino-propionic acid ethyl ester

There total 1 articles about 2-[6-(tert-butyl-dimethyl-silanyloxy)-benzo[1,3]dioxol-5-yl]-N-diphenylphosphinoyl-amino-propionic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

[6-(tert-butyldimethylsilanyloxy)benzo[1,3]dioxol-5-yl]-[(Z)-diphenylphosphorylimino]acetic acid ethyl ester (1258950-78-5) + methylmagnesium chloride (676-58-4) → 2-[6-(tert-butyl-dimethyl-silanyloxy)-benzo[1,3]dioxol-5-yl]-N-diphenylphosphinoyl-amino-propionic acid ethyl ester (1258950-79-6)

Guidance literature:

In tetrahydrofuran; toluene; at 0 ℃;

DOI:10.1002/chem.201001036

Reference yield:

2-[6-(tert-butyl-dimethyl-silanyloxy)-benzo[1,3]dioxol-5-yl]-N-diphenylphosphinoyl-amino-propionic acid ethyl ester (1258950-79-6) → (R)-7-diphenylphosphinoylamino-7-methyl-[1,3]dioxolo[4,5-f]benzofuran-6(7H)-one (1262219-57-7) + (S)-7-diphenylphosphinoylamino-7-methyl-[1,3]dioxolo[4,5-f]benzofuran-6(7H)-one

Guidance literature:

In N,N-dimethyl-formamide; for 5h; optical yield given as %ee; Inert atmosphere; Reflux;

DOI:10.1039/c0cc03399e

Reference yield:

2-[6-(tert-butyl-dimethyl-silanyloxy)-benzo[1,3]dioxol-5-yl]-N-diphenylphosphinoyl-amino-propionic acid ethyl ester (1258950-79-6) + lead(IV) tetraacetate (546-67-8) → 2-[2-acetoxy-6-(tert-butyldimethylsilanyloxy)benzo[1,3]dioxol-5-yl]-2-diphenylphosphinoylaminopropionic acid ethyl ester (1258950-80-9)

Guidance literature:

In benzene; at 80 ℃; for 4.5h;

DOI:10.1002/chem.201001036

upstream raw materials:

[6-(tert-butyldimethylsilanyloxy)benzo[1,3]dioxol-5-yl]-[(Z)-diphenylphosphorylimino]acetic acid ethyl ester

methylmagnesium chloride

Downstream raw materials:

2-[2-acetoxy-6-(tert-butyldimethylsilanyloxy)benzo[1,3]dioxol-5-yl]-2-diphenylphosphinoylaminopropionic acid ethyl ester

(R)-7-diphenylphosphinoylamino-7-methyl-[1,3]dioxolo[4,5-f]benzofuran-6(7H)-one