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Technology Process of 6-(3-chloro-phenyl)-8-[(4-chloro-phenyl)-hydroxy-(3-methyl-3H-imidazol-4-yl)-methyl]-2,3-dihydro-1-oxa-3a-aza-phenalen-4-one

6-(3-chloro-phenyl)-8-[(4-chloro-phenyl)-hydroxy-(3-methyl-3H-imidazol-4-yl)-methyl]-2,3-dihydro-1-oxa-3a-aza-phenalen-4-one

Base Information
  • Chemical Name:6-(3-chloro-phenyl)-8-[(4-chloro-phenyl)-hydroxy-(3-methyl-3H-imidazol-4-yl)-methyl]-2,3-dihydro-1-oxa-3a-aza-phenalen-4-one
  • CAS No.:213389-03-8
  • Molecular Formula:C28H21Cl2N3O3
  • Molecular Weight:518.399
  • Hs Code.:
6-(3-chloro-phenyl)-8-[(4-chloro-phenyl)-hydroxy-(3-methyl-3<i>H</i>-imidazol-4-yl)-methyl]-2,3-dihydro-1-oxa-3a-aza-phenalen-4-one

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Chemical Property of 6-(3-chloro-phenyl)-8-[(4-chloro-phenyl)-hydroxy-(3-methyl-3H-imidazol-4-yl)-methyl]-2,3-dihydro-1-oxa-3a-aza-phenalen-4-one
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Technology Process of 6-(3-chloro-phenyl)-8-[(4-chloro-phenyl)-hydroxy-(3-methyl-3H-imidazol-4-yl)-methyl]-2,3-dihydro-1-oxa-3a-aza-phenalen-4-one

There total 12 articles about 6-(3-chloro-phenyl)-8-[(4-chloro-phenyl)-hydroxy-(3-methyl-3H-imidazol-4-yl)-methyl]-2,3-dihydro-1-oxa-3a-aza-phenalen-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-Nitroanisole
91-23-6

2-Nitroanisole

6-(3-chloro-phenyl)-8-[(4-chloro-phenyl)-hydroxy-(3-methyl-3<i>H</i>-imidazol-4-yl)-methyl]-2,3-dihydro-1-oxa-3a-aza-phenalen-4-one
213389-03-8

6-(3-chloro-phenyl)-8-[(4-chloro-phenyl)-hydroxy-(3-methyl-3H-imidazol-4-yl)-methyl]-2,3-dihydro-1-oxa-3a-aza-phenalen-4-one

Guidance literature:
Multi-step reaction with 10 steps
1.1: AlCl3 / CH2Cl2
2.1: K2CO3 / acetonitrile
3.1: APTS / toluene
4.1: 27 percent / NaOH / methanol
5.1: 84 percent / H2; aq. HCl / Pt/C / tetrahydrofuran
6.1: toluene
7.1: tBuOK / 1,2-dimethoxy-ethane
8.1: n-BuLi; ClSiEt3 / tetrahydrofuran / -70 °C
8.2: 88 percent / n-BuLi / tetrahydrofuran / -70 °C
9.1: BBr3 / CH2Cl2
10.1: K2CO3 / dimethylformamide
With hydrogenchloride; sodium hydroxide; n-butyllithium; aluminium trichloride; triethylsilyl chloride; potassium tert-butylate; hydrogen; boron tribromide; potassium carbonate; 8-aminopyrene-1,3,6-trisulfonic acid, trisodium salt; platinum on activated charcoal; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; dichloromethane; N,N-dimethyl-formamide; toluene; acetonitrile; 1.1: Friedel-Crafts reaction;
DOI:10.1016/S0960-894X(03)00180-X

Reference yield:

3-chloro-benzonitrile
766-84-7

3-chloro-benzonitrile

6-(3-chloro-phenyl)-8-[(4-chloro-phenyl)-hydroxy-(3-methyl-3<i>H</i>-imidazol-4-yl)-methyl]-2,3-dihydro-1-oxa-3a-aza-phenalen-4-one
213389-03-8

6-(3-chloro-phenyl)-8-[(4-chloro-phenyl)-hydroxy-(3-methyl-3H-imidazol-4-yl)-methyl]-2,3-dihydro-1-oxa-3a-aza-phenalen-4-one

Guidance literature:
Multi-step reaction with 7 steps
1.1: 27 percent / NaOH / methanol
2.1: 84 percent / H2; aq. HCl / Pt/C / tetrahydrofuran
3.1: toluene
4.1: tBuOK / 1,2-dimethoxy-ethane
5.1: n-BuLi; ClSiEt3 / tetrahydrofuran / -70 °C
5.2: 88 percent / n-BuLi / tetrahydrofuran / -70 °C
6.1: BBr3 / CH2Cl2
7.1: K2CO3 / dimethylformamide
With hydrogenchloride; sodium hydroxide; n-butyllithium; triethylsilyl chloride; potassium tert-butylate; hydrogen; boron tribromide; potassium carbonate; platinum on activated charcoal; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; dichloromethane; N,N-dimethyl-formamide; toluene;
DOI:10.1016/S0960-894X(03)00180-X

Reference yield:

4-chloro-benzoyl chloride
122-01-0

4-chloro-benzoyl chloride

6-(3-chloro-phenyl)-8-[(4-chloro-phenyl)-hydroxy-(3-methyl-3<i>H</i>-imidazol-4-yl)-methyl]-2,3-dihydro-1-oxa-3a-aza-phenalen-4-one
213389-03-8

6-(3-chloro-phenyl)-8-[(4-chloro-phenyl)-hydroxy-(3-methyl-3H-imidazol-4-yl)-methyl]-2,3-dihydro-1-oxa-3a-aza-phenalen-4-one

Guidance literature:
Multi-step reaction with 10 steps
1.1: AlCl3 / CH2Cl2
2.1: K2CO3 / acetonitrile
3.1: APTS / toluene
4.1: 27 percent / NaOH / methanol
5.1: 84 percent / H2; aq. HCl / Pt/C / tetrahydrofuran
6.1: toluene
7.1: tBuOK / 1,2-dimethoxy-ethane
8.1: n-BuLi; ClSiEt3 / tetrahydrofuran / -70 °C
8.2: 88 percent / n-BuLi / tetrahydrofuran / -70 °C
9.1: BBr3 / CH2Cl2
10.1: K2CO3 / dimethylformamide
With hydrogenchloride; sodium hydroxide; n-butyllithium; aluminium trichloride; triethylsilyl chloride; potassium tert-butylate; hydrogen; boron tribromide; potassium carbonate; 8-aminopyrene-1,3,6-trisulfonic acid, trisodium salt; platinum on activated charcoal; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; dichloromethane; N,N-dimethyl-formamide; toluene; acetonitrile; 1.1: Friedel-Crafts reaction;
DOI:10.1016/S0960-894X(03)00180-X
upstream raw materials:

ethylene dibromide

4-(3-chloro-phenyl)-6-[(4-chloro-phenyl)-hydroxy-(3-methyl-3H-imidazol-4-yl)-methyl]-8-hydroxy-1H-quinolin-2-one

2-Nitroanisole

3-chloro-benzonitrile

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