ethyl 5-<2-chloro-4-phenylazo>-2,4-bis(ethoxycarbonyl)-3-thiopheneacetate

Base Information

• Chemical Name: ethyl 5-<2-chloro-4-phenylazo>-2,4-bis(ethoxycarbonyl)-3-thiopheneacetate
• CAS No.: 139174-95-1
• Molecular Formula: C₂₄H₃₀ClN₃O₈S
• Molecular Weight: 556.037
• Mol file: 139174-95-1.mol

Synonyms:

Chemical Property of ethyl 5-<2-chloro-4-phenylazo>-2,4-bis(ethoxycarbonyl)-3-thiopheneacetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl 5-<2-chloro-4-phenylazo>-2,4-bis(ethoxycarbonyl)-3-thiopheneacetate

There total 3 articles about ethyl 5-<2-chloro-4-phenylazo>-2,4-bis(ethoxycarbonyl)-3-thiopheneacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

ethyl 2-cyanoacetate (105-56-6) → ethyl 5-<2-chloro-4-phenylazo>-2,4-bis(ethoxycarbonyl)-3-thiopheneacetate (139174-95-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 87 percent / sulfur, diethylamine / ethanol / 2 h / 40 - 50 °C

2: 1.) nitrosyl hydrogensulfate, 2.) acetic acid / 1.) 0 deg C, 1 h, 2.) 0 deg C, 4 h

With nitrosylsulfuric acid; sulfur; acetic acid; diethylamine; In ethanol;

DOI:10.1246/bcsj.64.3768

Reference yield:

diethyl 1,3-acetonedicarboxylate (105-50-0) → ethyl 5-<2-chloro-4-phenylazo>-2,4-bis(ethoxycarbonyl)-3-thiopheneacetate (139174-95-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 87 percent / sulfur, diethylamine / ethanol / 2 h / 40 - 50 °C

2: 1.) nitrosyl hydrogensulfate, 2.) acetic acid / 1.) 0 deg C, 1 h, 2.) 0 deg C, 4 h

With nitrosylsulfuric acid; sulfur; acetic acid; diethylamine; In ethanol;

DOI:10.1246/bcsj.64.3768

Reference yield:

ethyl 2-amino-3,5-dicarbethoxythiophene-4-acetate (58168-14-2) + m-chloro-N,N-bis-β-hydroxyethylaniline (92-00-2) → ethyl 5-<2-chloro-4-phenylazo>-2,4-bis(ethoxycarbonyl)-3-thiopheneacetate (139174-95-1)

Guidance literature:

With nitrosylsulfuric acid; acetic acid; Yield given. Multistep reaction; 1.) 0 deg C, 1 h, 2.) 0 deg C, 4 h;

DOI:10.1246/bcsj.64.3768

upstream raw materials:

ethyl 2-amino-3,5-dicarbethoxythiophene-4-acetate

m-chloro-N,N-bis-β-hydroxyethylaniline

ethyl 2-cyanoacetate

diethyl 1,3-acetonedicarboxylate