Technology Process of tert-butyl cyclopropyl-[(2,2-dimethylpropionyl)-methyl-aminooxy]-acetate
There total 7 articles about tert-butyl cyclopropyl-[(2,2-dimethylpropionyl)-methyl-aminooxy]-acetate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
tert-butyl cyclopropyl-(2,2-dimethyl-propionylaminooxy)-acetate;
With
sodium hydride;
In
N,N-dimethyl-formamide;
at 20 ℃;
methyl iodide;
In
N,N-dimethyl-formamide;
at 20 ℃;
for 2h;
Further stages.;
DOI:10.1021/ol991392l
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: KMnO4; Na2CO3 / H2O / 24 h / 20 °C
2.1: (COCl)2; DMF / CH2Cl2 / 2.5 h / 20 °C
2.2: 64 percent / pyridine / CH2Cl2 / 20 h / 20 °C
3.1: 75 percent / NaCNBH3; HCl / methanol / 0.25 h / 20 °C
4.1: 71 percent / PPh3; DEAD / tetrahydrofuran / 23 h / 20 °C
5.1: NH2NH2*H2O / methanol / 0.25 h / 20 °C
6.1: 325 mg / aq. NaHCO3 / CH2Cl2 / 3 h / 20 °C
7.1: NaH / dimethylformamide / 20 °C
7.2: 56 percent / dimethylformamide / 2 h / 20 °C
With
hydrogenchloride; potassium permanganate; oxalyl dichloride; sodium hydride; sodium cyanoborohydride; sodium hydrogencarbonate; sodium carbonate; hydrazine hydrate; N,N-dimethyl-formamide; triphenylphosphine; diethylazodicarboxylate;
In
tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide;
1.1: Oxidation / 2.1: Substitution / 2.2: Esterification / 3.1: Reduction / 4.1: Condensation / 5.1: Substitution / 6.1: Condensation / 7.1: Metallation / 7.2: Methylation;
DOI:10.1021/ol991392l
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: (COCl)2; DMF / CH2Cl2 / 2.5 h / 20 °C
1.2: 64 percent / pyridine / CH2Cl2 / 20 h / 20 °C
2.1: 75 percent / NaCNBH3; HCl / methanol / 0.25 h / 20 °C
3.1: 71 percent / PPh3; DEAD / tetrahydrofuran / 23 h / 20 °C
4.1: NH2NH2*H2O / methanol / 0.25 h / 20 °C
5.1: 325 mg / aq. NaHCO3 / CH2Cl2 / 3 h / 20 °C
6.1: NaH / dimethylformamide / 20 °C
6.2: 56 percent / dimethylformamide / 2 h / 20 °C
With
hydrogenchloride; oxalyl dichloride; sodium hydride; sodium cyanoborohydride; sodium hydrogencarbonate; hydrazine hydrate; N,N-dimethyl-formamide; triphenylphosphine; diethylazodicarboxylate;
In
tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;
1.1: Substitution / 1.2: Esterification / 2.1: Reduction / 3.1: Condensation / 4.1: Substitution / 5.1: Condensation / 6.1: Metallation / 6.2: Methylation;
DOI:10.1021/ol991392l
