C₂₅H₂₂F₃NO₂

Base Information

Chemical Name:C₂₅H₂₂F₃NO₂
CAS No.:1552318-75-8
Molecular Formula:C₂₅H₂₂F₃NO₂
Molecular Weight:425.45
Hs Code.:

C<sub>25</sub>H<sub>22</sub>F<sub>3</sub>NO<sub>2</sub>

Synonyms:

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of C₂₅H₂₂F₃NO₂

Chemical Property:

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Technology Process of C₂₅H₂₂F₃NO₂

There total 4 articles about C₂₅H₂₂F₃NO₂ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 22.0%

: 1203685-30-6,1381927-79-2
C₁₂H₁₅NO₂*ClH

: 69231-87-4
4-bromo-4'-(trifluoromethyl)-1,1'-biphenyl

: 1552318-75-8
C₂₅H₂₂F₃NO₂

Guidance literature:: With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; sodium hexamethyldisilazane; DavePhos; In tetrahydrofuran; at 65 ℃; for 20h;
DOI:10.1016/j.bmcl.2013.12.090

Reference yield:

: 619-42-1
4-methoxycarbonylphenyl bromide

: 1552318-75-8
C₂₅H₂₂F₃NO₂

Guidance literature:: Multi-step reaction with 4 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / 1,2-dimethoxyethane; water / 3 h / Reflux

2: hydrogen; 5%-palladium/activated carbon / acetic acid / 24 h / 25 °C / 1551.49 Torr

3: hydrogenchloride / 1,4-dioxane; dichloromethane / 25 h / 25 °C

4: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; DavePhos; sodium hexamethyldisilazane / tetrahydrofuran / 20 h / 65 °C

With hydrogenchloride; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tetrakis(triphenylphosphine) palladium⁽⁰⁾; 5%-palladium/activated carbon; hydrogen; sodium hexamethyldisilazane; sodium carbonate; DavePhos; In tetrahydrofuran; 1,4-dioxane; 1,2-dimethoxyethane; dichloromethane; water; acetic acid; 1: |Suzuki Coupling;
DOI:10.1016/j.bmcl.2013.12.090

Reference yield:

: 1243198-96-0
2-(4-methoxycarbonylphenyl)pyrrolidine-1-carboxylic acid tert-butyl ester

: 1552318-75-8
C₂₅H₂₂F₃NO₂

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogenchloride / 1,4-dioxane; dichloromethane / 25 h / 25 °C

2: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; DavePhos; sodium hexamethyldisilazane / tetrahydrofuran / 20 h / 65 °C

With hydrogenchloride; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; sodium hexamethyldisilazane; DavePhos; In tetrahydrofuran; 1,4-dioxane; dichloromethane;
DOI:10.1016/j.bmcl.2013.12.090