C₃₂H₄₂O₄Si

Base Information

• Chemical Name: C₃₂H₄₂O₄Si
• CAS No.: 1642118-60-2
• Molecular Formula: C₃₂H₄₂O₄Si
• Molecular Weight: 518.769
• Mol file: 1642118-60-2.mol

Synonyms:

Chemical Property of C₃₂H₄₂O₄Si

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₃₂H₄₂O₄Si

There total 8 articles about C₃₂H₄₂O₄Si which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-O-[(tert-butyl)diphenylsilyl]-2,4-dideoxy-2-ethyl-3-O-(4-methoxybenzyl)-4-methyl-L-arabinitol (1620695-21-7) → C32H42O4Si (1642118-60-2)

Guidance literature:

1-O-[(tert-butyl)diphenylsilyl]-2,4-dideoxy-2-ethyl-3-O-(4-methoxybenzyl)-4-methyl-L-arabinitol; With oxalyl dichloride; dimethyl sulfoxide; In dichloromethane; at -78 ℃; for 1h;

With triethylamine; In dichloromethane; at -30 ℃;

DOI:10.1002/hlca.201300326

Reference yield:

(-)-Ethyl (4R)-(E)-4-Hydroxymethylhex-2-enoate (123001-19-4) → C32H42O4Si (1642118-60-2)

Guidance literature:

Multi-step reaction with 7 steps

1.1: 1H-imidazole / dichloromethane / 3 h / 0 - 20 °C

2.1: diisobutylaluminium hydride / dichloromethane; hexane / 2 h / -10 - 0 °C

3.1: D-(-)-diisopropyl tartrate; titanium(IV) isopropylate; Cumene hydroperoxide / dichloromethane / 3 h / -20 °C / Molecular sieve

4.1: copper(l) iodide / hexane; diethyl ether / 20 h / -20 °C

4.2: 10 h / 20 °C

5.1: toluene-4-sulfonic acid / dichloromethane / 2 h / 20 °C

6.1: diisobutylaluminium hydride / dichloromethane; hexane / 3 h / -20 - 0 °C

7.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 1 h / -78 °C

7.2: -30 °C

With 1H-imidazole; titanium(IV) isopropylate; copper(l) iodide; oxalyl dichloride; Cumene hydroperoxide; diisobutylaluminium hydride; D-(-)-diisopropyl tartrate; toluene-4-sulfonic acid; dimethyl sulfoxide; In diethyl ether; hexane; dichloromethane; 3.1: |Sharpless Asymmetric Epoxidation / 7.1: |Swern Oxidation / 7.2: |Swern Oxidation;

DOI:10.1002/hlca.201300326

Reference yield:

(2S,3S)-3-ethylbutane-1,2,4-triol (1192050-18-2) → C32H42O4Si (1642118-60-2)

Guidance literature:

Multi-step reaction with 9 steps

1.1: sodium periodate; sodium hydrogencarbonate / dichloromethane; water / 10 h / 0 - 20 °C

2.1: dichloromethane / 3 h / 0 - 20 °C

3.1: 1H-imidazole / dichloromethane / 3 h / 0 - 20 °C

4.1: diisobutylaluminium hydride / dichloromethane; hexane / 2 h / -10 - 0 °C

5.1: D-(-)-diisopropyl tartrate; titanium(IV) isopropylate; Cumene hydroperoxide / dichloromethane / 3 h / -20 °C / Molecular sieve

6.1: copper(l) iodide / hexane; diethyl ether / 20 h / -20 °C

6.2: 10 h / 20 °C

7.1: toluene-4-sulfonic acid / dichloromethane / 2 h / 20 °C

8.1: diisobutylaluminium hydride / dichloromethane; hexane / 3 h / -20 - 0 °C

9.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 1 h / -78 °C

9.2: -30 °C

With 1H-imidazole; titanium(IV) isopropylate; sodium periodate; copper(l) iodide; oxalyl dichloride; Cumene hydroperoxide; diisobutylaluminium hydride; sodium hydrogencarbonate; D-(-)-diisopropyl tartrate; toluene-4-sulfonic acid; dimethyl sulfoxide; In diethyl ether; hexane; dichloromethane; water; 2.1: |Wittig Olefination / 5.1: |Sharpless Asymmetric Epoxidation / 9.1: |Swern Oxidation / 9.2: |Swern Oxidation;

DOI:10.1002/hlca.201300326

upstream raw materials:

(-)-Ethyl (4R)-(E)-4-Hydroxymethylhex-2-enoate

(2S,3S)-3-ethylbutane-1,2,4-triol

ethyl (2E,4R)-4-({[(tert-butyl)diphenylsilyl]oxy}methyl)hex-2-enoate

1-O-[(tert-butyl)diphenylsilyl]-2,4-dideoxy-2-ethyl-4-methyl-L-arabinitol

Downstream raw materials:

methyl (2Z,4S,5S,6S,9S)-9-(benzyloxy)-10-[(4R)-2,2-dimethyl-1,3-dioxolan-4-yl]-4-ethyl-5-[(4-methoxybenzyl)oxy]-6-methyldec-2-enoate

C₃₁H₄₄O₆

(tert-butyl)({(2S,3S,4S)-2-ethyl-3-[(4-methoxybenzyl)oxy]-4-methylhex-5-en-1-yl}oxy)diphenylsilane