2-(4-methoxyphenyl)-1-(piperazin-1-yl)ethan-1-one

Base Information

• Chemical Name: 2-(4-methoxyphenyl)-1-(piperazin-1-yl)ethan-1-one
• CAS No.: 119784-75-7
• Molecular Formula: C₁₃H₁₈N₂O₂
• Molecular Weight: 234.298
• Mol file: 119784-75-7.mol

Synonyms:

Chemical Property of 2-(4-methoxyphenyl)-1-(piperazin-1-yl)ethan-1-one

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

2-(4-Methoxyphenyl)-1-(piperazin-1-yl)ethanone 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(4-methoxyphenyl)-1-(piperazin-1-yl)ethan-1-one

There total 3 articles about 2-(4-methoxyphenyl)-1-(piperazin-1-yl)ethan-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C18H26N2O4 (1327699-52-4) → 2-(4-methoxyphenyl)-1-(piperazin-1-yl)ethanone (119784-75-7)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 25 ℃;

DOI:10.1016/j.bmcl.2014.07.001

Reference yield:

4-Methoxyphenylacetic acid (104-01-8) → 2-(4-methoxyphenyl)-1-(piperazin-1-yl)ethanone (119784-75-7)

Guidance literature:

Multi-step reaction with 2 steps

1.1: 0.08 h / 20 °C / Neat (no solvent)

2.1: water / 0.08 h

2.2: 0.5 h

In water;

DOI:10.1039/c1gc16314k

Reference yield:

piperazine (110-85-0) + 1-(1H-imidazol-1-yl)-2-(4-methoxyphenyl)ethan-1-one (123331-31-7) + piperazine dihydrochloride (142-64-3,8006-71-1) → 2-(4-methoxyphenyl)-1-(piperazin-1-yl)ethanone (119784-75-7)

Guidance literature:

piperazine; piperazine dihydrochloride; In water; for 0.0833333h;

1-(1H-imidazol-1-yl)-2-(4-methoxyphenyl)ethan-1-one; With sodium chloride; In water; for 0.5h;

With sodium hydroxide; In water; chemoselective reaction;

DOI:10.1039/c1gc16314k

upstream raw materials:

piperazine

1-(1H-imidazol-1-yl)-2-(4-methoxyphenyl)ethan-1-one

piperazine dihydrochloride

4-Methoxyphenylacetic acid

Downstream raw materials:

C₂₇H₂₆N₄O₄S

Refernces

• 1、 Wang, Ling-Xiao,Zhou, Xin-Bo,Xiao, Meng-Liang,Jiang, Ning,Liu, Feng,Zhou, Wen-Xia,Wang, Xiao-Kui,Zheng, Zhi-Bing,Li, Song. "Synthesis and biological evaluation of substituted 4-(thiophen-2-ylmethyl)- 2H-phthalazin-1-ones as potent PARP-1 inhibitors". . p. 3739 - 3743. Retrieved 2014/09/17.