2-cyclopropylamino-4-fluorobenzenesulphonamide

Base Information

• Chemical Name: 2-cyclopropylamino-4-fluorobenzenesulphonamide
• CAS No.: 1204572-62-2
• Molecular Formula: C₉H₁₁FN₂O₂S
• Molecular Weight: 230.263
• Mol file: 1204572-62-2.mol

Synonyms:

Chemical Property of 2-cyclopropylamino-4-fluorobenzenesulphonamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-cyclopropylamino-4-fluorobenzenesulphonamide

There total 4 articles about 2-cyclopropylamino-4-fluorobenzenesulphonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2,4-difluorophenylamine (367-25-9,76563-56-9) → 2-cyclopropylamino-4-fluorobenzenesulphonamide (1204572-62-2)

Guidance literature:

Multi-step reaction with 3 steps

1.1: acetic acid; hydrogenchloride; sodium nitrite / water / -5 °C

1.2: 0.25 h / Cooling with ice

2.1: ammonium hydroxide / 1,4-dioxane / 0.5 h / Cooling

3.1: 1,4-dioxane / 24 h / 100 - 110 °C

With hydrogenchloride; ammonium hydroxide; acetic acid; sodium nitrite; In 1,4-dioxane; water;

DOI:10.1021/ci500559b

Reference yield:

2,4-difluorobenzene-1-sulfonyl chloride (13918-92-8) → 2-cyclopropylamino-4-fluorobenzenesulphonamide (1204572-62-2)

Guidance literature:

Multi-step reaction with 2 steps

1: ammonium hydroxide / 1,4-dioxane / 0.5 h / Cooling

2: 1,4-dioxane / 24 h / 100 - 110 °C

With ammonium hydroxide; In 1,4-dioxane;

DOI:10.1021/ci500559b

Reference yield:

2,4-difluoro-1-benzenesulfonamide (13656-60-5) + Cyclopropylamine (765-30-0) → 2-cyclopropylamino-4-fluorobenzenesulphonamide (1204572-62-2)

Guidance literature:

In 1,4-dioxane; at 100 - 110 ℃; for 24h;

DOI:10.1021/ci500559b

upstream raw materials:

2,4-difluorobenzene-1-sulfonyl chloride

2,4-difluoro-1-benzenesulfonamide

Cyclopropylamine

2,4-difluorophenylamine

Refernces

• 1、 -. "Cycloalkylated benzothiadiazines, a process for their preparation and pharmaceutical compostions containing them". Page/Page column 5. . Retrieved 2010/02/17.