Technology Process of 6-chloro-9-[3-deoxy-2-O-(sulfurylimidazolyl)-5-O-(triphenylmethyl)-β-D-erythro-pentofuranosyl]-9H-purine
There total 6 articles about 6-chloro-9-[3-deoxy-2-O-(sulfurylimidazolyl)-5-O-(triphenylmethyl)-β-D-erythro-pentofuranosyl]-9H-purine which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
6-chloro-9-[3-deoxy-5-O-(triphenylmethyl)-β-D-erythro-pentofuranosyl]-9H-purine;
With
sulfuryl dichloride;
In
pyridine; dichloromethane;
at -35 ℃;
for 0.5h;
1H-imidazole;
In
dichloromethane;
at 20 ℃;
for 20.5h;
Further stages.;
DOI:10.1021/jo0158985
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: 67 percent / Bu3SnH; AIBN / toluene / 2 h / 90 °C
2.1: 99 percent / N,N-dimethylaniline; Et4NCl; POCl3 / acetonitrile / 2 h / Heating
3.1: 94.1 percent / 28percent NaOMe / methanol / 3 h / 20 °C
4.1: 85.1 percent / 2,4,6-collidine / acetonitrile / 3 h / 45 °C
5.1: SO2Cl2 / pyridine; CH2Cl2 / 0.5 h / -35 °C
5.2: 790 mg / CH2Cl2 / 20.5 h / 20 °C
With
2,4,6-trimethyl-pyridine; sulfuryl dichloride; 2,2'-azobis(isobutyronitrile); tetraethylammonium chloride; tri-n-butyl-tin hydride; N,N-dimethyl-aniline; trichlorophosphate;
In
pyridine; methanol; dichloromethane; toluene; acetonitrile;
DOI:10.1021/jo0158985
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: AcOH / 5 h / 50 °C
1.2: 80 percent / AcBr / acetonitrile / 4 h / 10 °C
2.1: 67 percent / Bu3SnH; AIBN / toluene / 2 h / 90 °C
3.1: 99 percent / N,N-dimethylaniline; Et4NCl; POCl3 / acetonitrile / 2 h / Heating
4.1: 94.1 percent / 28percent NaOMe / methanol / 3 h / 20 °C
5.1: 85.1 percent / 2,4,6-collidine / acetonitrile / 3 h / 45 °C
6.1: SO2Cl2 / pyridine; CH2Cl2 / 0.5 h / -35 °C
6.2: 790 mg / CH2Cl2 / 20.5 h / 20 °C
With
2,4,6-trimethyl-pyridine; sulfuryl dichloride; 2,2'-azobis(isobutyronitrile); tetraethylammonium chloride; tri-n-butyl-tin hydride; acetic acid; N,N-dimethyl-aniline; trichlorophosphate;
In
pyridine; methanol; dichloromethane; toluene; acetonitrile;
DOI:10.1021/jo0158985
