C₁₆H₁₄N₄O₃

Base Information

• Chemical Name: C₁₆H₁₄N₄O₃
• CAS No.: 1316649-76-9
• Molecular Formula: C₁₆H₁₄N₄O₃
• Molecular Weight: 310.312
• Mol file: 1316649-76-9.mol

Synonyms:

Chemical Property of C₁₆H₁₄N₄O₃

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₁₆H₁₄N₄O₃

There total 4 articles about C₁₆H₁₄N₄O₃ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

propynoic acid hydroxyamide (216970-08-0) + 4-phenoxybenzyl azide (1254305-69-5) → C16H14N4O3 (1316649-76-9)

Guidance literature:

With copper(II) sulfate; sodium L-ascorbate; tris[(1-benzyl-1H-1,2,3-triazol-4yl)methyl]amine; In water; dimethyl sulfoxide; at 20 ℃; Combinatorial reaction / High throughput screening (HTS);

DOI:10.1021/jm300837y

Reference yield:

4-Phenoxybenzoic acid (2215-77-2) → C16H14N4O3 (1316649-76-9)

Guidance literature:

Multi-step reaction with 3 steps

1: lithium aluminium tetrahydride / tetrahydrofuran / 7 h / Reflux

2: diphenyl phosphoryl azide; 1,8-diazabicyclo[5.4.0]undec-7-ene / N,N-dimethyl-formamide / 24 h / 0 - 20 °C / Inert atmosphere

3: copper(II) sulfate; tris[(1-benzyl-1H-1,2,3-triazol-4yl)methyl]amine; sodium L-ascorbate / water; dimethyl sulfoxide / 20 °C / Combinatorial reaction / High throughput screening (HTS)

With lithium aluminium tetrahydride; diphenyl phosphoryl azide; copper(II) sulfate; 1,8-diazabicyclo[5.4.0]undec-7-ene; sodium L-ascorbate; tris[(1-benzyl-1H-1,2,3-triazol-4yl)methyl]amine; In tetrahydrofuran; water; dimethyl sulfoxide; N,N-dimethyl-formamide;

DOI:10.1021/jm300837y

Reference yield:

(4-phenoxyphenyl)methanol (2215-78-3) → C16H14N4O3 (1316649-76-9)

Guidance literature:

Multi-step reaction with 2 steps

1: diphenyl phosphoryl azide; 1,8-diazabicyclo[5.4.0]undec-7-ene / N,N-dimethyl-formamide / 24 h / 0 - 20 °C / Inert atmosphere

2: copper(II) sulfate; tris[(1-benzyl-1H-1,2,3-triazol-4yl)methyl]amine; sodium L-ascorbate / water; dimethyl sulfoxide / 20 °C / Combinatorial reaction / High throughput screening (HTS)

With diphenyl phosphoryl azide; copper(II) sulfate; 1,8-diazabicyclo[5.4.0]undec-7-ene; sodium L-ascorbate; tris[(1-benzyl-1H-1,2,3-triazol-4yl)methyl]amine; In water; dimethyl sulfoxide; N,N-dimethyl-formamide;

DOI:10.1021/jm300837y

upstream raw materials:

4-Phenoxybenzoic acid

(4-phenoxyphenyl)methanol

propynoic acid hydroxyamide

4-phenoxybenzyl azide