{(2R,3S)-2-[2-(tert-Butyl-dimethyl-silanyloxy)-2-cyclopropyl-ethyl]-3-[1-(2-nitro-benzyloxycarbonyloxy)-ethyl]-4-oxo-azetidin-1-yl}-hydroxy-acetic acid 2-nitro-benzyl ester

Base Information

Chemical Name:{(2R,3S)-2-[2-(tert-Butyl-dimethyl-silanyloxy)-2-cyclopropyl-ethyl]-3-[1-(2-nitro-benzyloxycarbonyloxy)-ethyl]-4-oxo-azetidin-1-yl}-hydroxy-acetic acid 2-nitro-benzyl ester
CAS No.:91504-11-9
Molecular Formula:C₃₃H₄₃N₃O₁₂Si
Molecular Weight:701.803
Hs Code.:

{(2R,3S)-2-[2-(tert-Butyl-dimethyl-silanyloxy)-2-cyclopropyl-ethyl]-3-[1-(2-nitro-benzyloxycarbonyloxy)-ethyl]-4-oxo-azetidin-1-yl}-hydroxy-acetic acid 2-nitro-benzyl ester

Synonyms:

Suppliers and Price of {(2R,3S)-2-[2-(tert-Butyl-dimethyl-silanyloxy)-2-cyclopropyl-ethyl]-3-[1-(2-nitro-benzyloxycarbonyloxy)-ethyl]-4-oxo-azetidin-1-yl}-hydroxy-acetic acid 2-nitro-benzyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of {(2R,3S)-2-[2-(tert-Butyl-dimethyl-silanyloxy)-2-cyclopropyl-ethyl]-3-[1-(2-nitro-benzyloxycarbonyloxy)-ethyl]-4-oxo-azetidin-1-yl}-hydroxy-acetic acid 2-nitro-benzyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of {(2R,3S)-2-[2-(tert-Butyl-dimethyl-silanyloxy)-2-cyclopropyl-ethyl]-3-[1-(2-nitro-benzyloxycarbonyloxy)-ethyl]-4-oxo-azetidin-1-yl}-hydroxy-acetic acid 2-nitro-benzyl ester

There total 15 articles about {(2R,3S)-2-[2-(tert-Butyl-dimethyl-silanyloxy)-2-cyclopropyl-ethyl]-3-[1-(2-nitro-benzyloxycarbonyloxy)-ethyl]-4-oxo-azetidin-1-yl}-hydroxy-acetic acid 2-nitro-benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 67502-20-9
o-nitrobenzyl glyoxalate

: 91504-10-8
Carbonic acid 1-{(2R,3S)-2-[2-(tert-butyl-dimethyl-silanyloxy)-2-cyclopropyl-ethyl]-4-oxo-azetidin-3-yl}-ethyl ester 2-nitro-benzyl ester

: 91504-11-9
{(2R,3S)-2-[2-(tert-Butyl-dimethyl-silanyloxy)-2-cyclopropyl-ethyl]-3-[1-(2-nitro-benzyloxycarbonyloxy)-ethyl]-4-oxo-azetidin-1-yl}-hydroxy-acetic acid 2-nitro-benzyl ester

Guidance literature:: In benzene; for 8h; Heating; azeotropic removal of water;
DOI:10.1016/S0040-4039(01)81132-1

Reference yield:

: 64221-82-5
4-(2-acetoxy-(E)-vinyl)-2-azetidinone

: 91504-11-9
{(2R,3S)-2-[2-(tert-Butyl-dimethyl-silanyloxy)-2-cyclopropyl-ethyl]-3-[1-(2-nitro-benzyloxycarbonyloxy)-ethyl]-4-oxo-azetidin-1-yl}-hydroxy-acetic acid 2-nitro-benzyl ester

Guidance literature:: Multi-step reaction with 13 steps

1: 100 percent / H₂ / 10percent Pd/C / ethyl acetate / 3 h

2: 90 percent / NaOMe / methanol / 1 h / 0 °C

3: tetrahydrofuran

4: triethylamine / dimethylformamide / Ambient temperature

5: 30percent aqueous acetic acid / methanol / 0.5 h / Ambient temperature

6: 44 percent / chromium trioxide dipyridine complex / CH₂Cl₂ / 0.5 h / 0 °C

7: 85 percent / tetrahydrofuran; diethyl ether / Ambient temperature

8: 90 percent / triethylamine / dimethylformamide / 6 h

9: 70 percent / lithium diisopropylamide / tetrahydrofuran / -78 °C

10: 4-(N,N-dimethylamino)pyridine / CH₂Cl₂ / 1.5 h

11: 90 percent / 2.5N HCl / methanol

12: imidazole / dimethylformamide

13: 95 percent / benzene / 8 h / Heating; azeotropic removal of water

With 1H-imidazole; hydrogenchloride; dmap; 2,2'-bipyridine-chromium(VI) oxide; hydrogen; sodium methylate; acetic acid; triethylamine; lithium diisopropyl amide; palladium on activated charcoal; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; benzene;
DOI:10.1016/S0040-4039(01)81132-1

Reference yield:

: 42854-99-9
o-nitrobenzyl chloroformate

: 91504-11-9
{(2R,3S)-2-[2-(tert-Butyl-dimethyl-silanyloxy)-2-cyclopropyl-ethyl]-3-[1-(2-nitro-benzyloxycarbonyloxy)-ethyl]-4-oxo-azetidin-1-yl}-hydroxy-acetic acid 2-nitro-benzyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 4-(N,N-dimethylamino)pyridine / CH₂Cl₂ / 1.5 h

2: 90 percent / 2.5N HCl / methanol

3: imidazole / dimethylformamide

4: 95 percent / benzene / 8 h / Heating; azeotropic removal of water

With 1H-imidazole; hydrogenchloride; dmap; In methanol; dichloromethane; N,N-dimethyl-formamide; benzene;
DOI:10.1016/S0040-4039(01)81132-1