Nifedipine pyrimidine impurity

Base Information

Chemical Name:Nifedipine pyrimidine impurity
CAS No.:80742-11-6
Molecular Formula:C₁₉H₁₈N₄O₆
Molecular Weight:398.375
Hs Code.:
UNII:EXL67I47IK

Synonyms:Nifedipine pyrimidine impurity;Nifedipine pyrimidine;EXL67I47IK;5-Pyrimidinecarboxylic acid, 1,2,3,4-tetrahydro-6-methyl-2,4-bis(2-nitrophenyl)-, methyl ester;5-Pyrimidinecarboxylic acid, 1,2,3,4-tetrahydro-6-methyl-2,4-bis(2-nitrophenyl)-, methyl ester, (2R,4R)-rel-;5-Pyrimidinecarboxylic acid, 1,2,3,4-tetrahydro-6-methyl-2,4-bis(2-nitrophenyl)-, methyl ester, cis-(+/-)-;80742-11-6;UNII-EXL67I47IK

Suppliers and Price of Nifedipine pyrimidine impurity

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
(2R,4R)-rel-1,2,3,4-Tetrahydro-6-methyl-2,4-bis(2-nitrophenyl)-5-pyrimidinecarboxylicAcidMethylEster
250mg
$ 180.00

American Custom Chemicals Corporation
NIFEDIPINE PYRIMIDINE IMPURITY 95.00%
5MG
$ 452.35

Total 5 raw suppliers

Chemical Property of Nifedipine pyrimidine impurity

Chemical Property:

Boiling Point:572.8±50.0 °C(Predicted)
Density:1.339±0.06 g/cm3(Predicted)
XLogP3:2.8
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:8
Rotatable Bond Count:4
Exact Mass:398.12263431
Heavy Atom Count:29
Complexity:685

Purity/Quality:

> 95% ^*data from raw suppliers

(2R,4R)-rel-1,2,3,4-Tetrahydro-6-methyl-2,4-bis(2-nitrophenyl)-5-pyrimidinecarboxylicAcidMethylEster ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC1=C(C(NC(N1)C2=CC=CC=C2[N+](=O)[O-])C3=CC=CC=C3[N+](=O)[O-])C(=O)OC
Isomeric SMILES:CC1=C([C@@H](N[C@@H](N1)C2=CC=CC=C2[N+](=O)[O-])C3=CC=CC=C3[N+](=O)[O-])C(=O)OC
Uses (2R,4R)-rel-1,2,3,4-Tetrahydro-6-methyl-2,4-bis(2-nitrophenyl)-5-pyrimidinecarboxylic Acid Methyl Ester is an impurity of Nifedipine (N457000); a dihydropyridine calcium channel blocker. Also used as an antihypertensive and antianginal.

Technology Process of Nifedipine pyrimidine impurity

There total 8 articles about Nifedipine pyrimidine impurity which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.3%

: 105-45-3
acetoacetic acid methyl ester

: 552-89-6
2-nitro-benzaldehyde

: 21829-25-4
nifedipine

: 80742-11-6,80742-13-8,108139-78-2
6-Methyl-2,4-bis-(2-nitrophenyl)-1,2,3,4-tetrahydropyrimidin-5-carbonsaeuremethylester

Guidance literature:: With ammonium hydroxide; In ethanol; for 24h; Yields of byproduct given; Ambient temperature;
DOI:10.1002/ardp.19813141109