(±)-cephalotaxinone

Base Information

• Chemical Name: (±)-cephalotaxinone
• CAS No.: 38848-26-9
• Molecular Formula: C₁₈H₁₉NO₄
• Molecular Weight: 313.353
• Mol file: 38848-26-9.mol

Synonyms:

Chemical Property of (±)-cephalotaxinone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (±)-cephalotaxinone

There total 40 articles about (±)-cephalotaxinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

Trimethylmethoxysilane (1825-61-2) + (±)-demethylcephalotaxinone (38848-25-8) → (±)-cephalotaxinone (38750-57-1,38848-26-9)

Guidance literature:

With trifluorormethanesulfonic acid; In dichloromethane; at 0 - 40 ℃; Inert atmosphere;

DOI:10.1021/acs.orglett.5b02106

Reference yield: 84.0%

(±)-demethylcephalotaxinone (38848-25-8) + 2,2-dimethoxy-propane (77-76-9) → (±)-cephalotaxinone (38750-57-1,38848-26-9)

Guidance literature:

With toluene-4-sulfonic acid; In 1,4-dioxane; for 22.5h; Heating;

Reference yield: 60.0%

33-methoxy-7-aza-1(5,6)-benzo[d] [1,3]dioxola-3(2,5)-furanacyclononaphane → (±)-cephalotaxinone (38750-57-1,38848-26-9)

Guidance literature:

With 2,3-dicyano-5,6-dichloro-p-benzoquinone; In 2,2,2-trifluoroethanol; at 50 ℃; for 15h; Inert atmosphere;

DOI:10.1002/anie.201902174

upstream raw materials:

cephalotaxine

(±)-demethylcephalotaxinone

2,2-dimethoxy-propane

(1α,2α,3R*,14bα)-(+/-)-1,2,3,5,6,8,9,14b-octahydro-4H-cyclopenta<1,3>dioxolo<4,5-h>pyrrolo<2,1-b><3>benzazepine-1,2-diol

Downstream raw materials:

(1S,3aR,14bS)-2-methoxy-1,5,6,8,9,14b-hexahydro-4H-[1,3]dioxolo[4',5':4,5]benzo[1,2-d]cyclopenta[b]pyrrolo[1,2-a]azepin-1-yl (R)-2-((E)-4-(benzyloxy)-4-methylpent-2-en-1-yl)-4-oxooxetane-2-carboxylate

1-((1S,3aR,14bS)-2-methoxy-1,5,6,8,9,14b-hexahydro-4H-[1,3]dioxolo[4',5':4,5]benzo[1,2-d]cyclopenta[b]pyrrolo[1,2-a]azepin-1-yl) 4-methyl (R)-2-((E)-4-(benzyloxy)-4-methylpent-2-en-1-yl)-2-hydroxysuccinate

homoharringtonine

cephalotaxine