1-(1-phenylcycloheptyl)piperidine hydrochloride

Base Information

• Chemical Name: 1-(1-phenylcycloheptyl)piperidine hydrochloride
• CAS No.: 79798-00-8
• Molecular Formula: C₁₈H₂₇N*ClH
• Molecular Weight: 293.88
• Mol file: 79798-00-8.mol

Synonyms:

Chemical Property of 1-(1-phenylcycloheptyl)piperidine hydrochloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(1-phenylcycloheptyl)piperidine hydrochloride

There total 5 articles about 1-(1-phenylcycloheptyl)piperidine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-phenylcycloheptanamine (59397-23-8) → 1-(1-phenylcycloheptyl)piperidine hydrochloride (79798-00-8)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium carbonate; triethylamine / acetonitrile / 20 °C

2: hydrogenchloride / diethyl ether

With hydrogenchloride; potassium carbonate; triethylamine; In diethyl ether; acetonitrile;

DOI:10.2174/1573406410666140428104444

Reference yield:

bromobenzene (108-86-1,52753-63-6) → 1-(1-phenylcycloheptyl)piperidine hydrochloride (79798-00-8)

Guidance literature:

Multi-step reaction with 5 steps

1.1: iodine; magnesium / tetrahydrofuran / 24 h / 0 °C / Inert atmosphere

1.2: 24 h / 0 °C / Inert atmosphere

2.1: sodium azide; trifluoroacetic acid / chloroform / 0 - 20 °C

3.1: lithium aluminium tetrahydride / tetrahydrofuran / 12 h / 0 - 20 °C / Inert atmosphere

4.1: potassium carbonate; triethylamine / acetonitrile / 20 °C

5.1: hydrogenchloride / diethyl ether

With hydrogenchloride; lithium aluminium tetrahydride; sodium azide; iodine; potassium carbonate; magnesium; triethylamine; trifluoroacetic acid; In tetrahydrofuran; diethyl ether; chloroform; acetonitrile;

DOI:10.2174/1573406410666140428104444

Reference yield:

1-phenylcycloheptanol (2082-21-5) → 1-(1-phenylcycloheptyl)piperidine hydrochloride (79798-00-8)

Guidance literature:

Multi-step reaction with 4 steps

1: sodium azide; trifluoroacetic acid / chloroform / 0 - 20 °C

2: lithium aluminium tetrahydride / tetrahydrofuran / 12 h / 0 - 20 °C / Inert atmosphere

3: potassium carbonate; triethylamine / acetonitrile / 20 °C

4: hydrogenchloride / diethyl ether

With hydrogenchloride; lithium aluminium tetrahydride; sodium azide; potassium carbonate; triethylamine; trifluoroacetic acid; In tetrahydrofuran; diethyl ether; chloroform; acetonitrile;

DOI:10.2174/1573406410666140428104444

upstream raw materials:

1-phenylcycloheptanamine

bromobenzene

1-phenylcycloheptanol

1-Azido-1-phenyl-cycloheptane