1-phenylcycloheptanamine

Base Information

• Chemical Name: 1-phenylcycloheptanamine
• CAS No.: 59397-23-8
• Molecular Formula: C13H19 N
• Molecular Weight: 189.301
• Mol file: 59397-23-8.mol

Synonyms:1-Phenylcycloheptylamine;NSC 279902

Chemical Property of 1-phenylcycloheptanamine

Chemical Property:

• Vapor Pressure: 0.00186mmHg at 25°C
• Boiling Point: 292.2°Cat760mmHg
• Flash Point: 132.9°C
• Density: 0.973g/cm³

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-phenylcycloheptanamine

There total 8 articles about 1-phenylcycloheptanamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-phenylcycloheptanol (2082-21-5) → 1-phenylcycloheptanamine (59397-23-8)

Guidance literature:

Multistep reaction; (i) NaN₃, CF₃CO₂H, CHCl₃, (ii) Raney-Ni, iPrOH;

DOI:10.1055/s-1978-24654

Reference yield:

cycloheptanone (502-42-1) → 1-phenylcycloheptanamine (59397-23-8)

Guidance literature:

Multi-step reaction with 3 steps

1: tetrahydrofuran / 0.33 h

2: NaN₃, CF₃COOH / CHCl₃ / Ambient temperature

3: LiAlH₄ / diethyl ether / 3 h

With lithium aluminium tetrahydride; sodium azide; trifluoroacetic acid; In tetrahydrofuran; diethyl ether; chloroform;

DOI:10.1021/jm00167a027

Reference yield:

phenylmagnesium bromide (100-58-3) → 1-phenylcycloheptanamine (59397-23-8)

Guidance literature:

Multi-step reaction with 3 steps

1: tetrahydrofuran

2: sodium azide; trifluoroacetic acid / chloroform / 0 - 20 °C

3: lithium aluminium tetrahydride / tetrahydrofuran / 3.17 h

With lithium aluminium tetrahydride; sodium azide; trifluoroacetic acid; In tetrahydrofuran; chloroform;

DOI:10.1021/acs.orglett.7b02339

upstream raw materials:

1-phenylcycloheptanol

cycloheptanone

7-Brom-1-phenyl-1-heptancarbonitril

phenylacetonitrile

Downstream raw materials:

1-(1-phenylcycloheptyl)piperidine hydrochloride

N-cycloheptylidenebenzenamine

1-(1-phenylcycloheptyl)piperidin-4-one

1,1'-Diphenyl-1,1'-bicycloheptyl