C₁₈H₁₆F₂NO₄P

Base Information

• Chemical Name: C₁₈H₁₆F₂NO₄P
• CAS No.: 100072-90-0
• Molecular Formula: C₁₈H₁₆F₂NO₄P
• Molecular Weight: 379.3
• Mol file: 100072-90-0.mol

Synonyms:

Chemical Property of C₁₈H₁₆F₂NO₄P

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₁₈H₁₆F₂NO₄P

There total 3 articles about C₁₈H₁₆F₂NO₄P which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-fluorobenzaldehyde (459-57-4) → C18H16F2NO4P (100072-90-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) KCN, 2.) conc. nitric acid / 1.) EtOH, H₂O, heated, 30 min, 2.) glacial acetic acid, heated, 5 h

2: CD₂Cl₂ / 0.08 h / -78 °C

With potassium cyanide; nitric acid; In dichloromethane-d2;

Reference yield:

4-methoxy-benzaldehyde (123-11-5) → C18H16F2NO4P (100072-90-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) KCN, 2.) conc. nitric acid / 1.) EtOH, H₂O, heated, 30 min, 2.) glacial acetic acid, heated, 5 h

2: CD₂Cl₂ / 0.08 h / -78 °C

With potassium cyanide; nitric acid; In dichloromethane-d2;

Reference yield:

1,2-bis(4-fluorophenyl)ethane-1,2-dione (579-39-5) + 2,8-dioxa-5-aza-1-phosphabicyclo<3.3.0>octane (65693-26-7) → C18H16F2NO4P (100072-90-0)

Guidance literature:

In dichloromethane-d2; at -78 ℃; for 0.0833333h;

upstream raw materials:

1,2-bis(4-fluorophenyl)ethane-1,2-dione

2,8-dioxa-5-aza-1-phosphabicyclo<3.3.0>octane

4-fluorobenzaldehyde

4-methoxy-benzaldehyde

Refernces