allopregnane-3beta,17alpha,20beta,21-tetrol

Base Information

• Chemical Name: allopregnane-3beta,17alpha,20beta,21-tetrol
• CAS No.: 566-41-6
• Molecular Formula: C21H36 O4
• Molecular Weight: 352.514
• Mol file: 566-41-6.mol

Synonyms:5a-Pregnane-3b,17,20b,21-tetrol (8CI);17-(1,2-Dihydroxyethyl)androstane-3,17-diol; Allopregnane-3b,17a,20b,21-tetrol; Reichstein's substance K

Chemical Property of allopregnane-3beta,17alpha,20beta,21-tetrol

Chemical Property:

• Vapor Pressure: 3.49E-13mmHg at 25°C
• Melting Point: 198-200°
• Boiling Point: 524.3°Cat760mmHg
• PKA: 14.22±0.70(Predicted)
• Flash Point: 235.7°C
• PSA: 80.92000
• Density: 1.186g/cm³
• LogP: 2.47430

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of allopregnane-3beta,17alpha,20beta,21-tetrol

There total 22 articles about allopregnane-3beta,17alpha,20beta,21-tetrol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ Epiandrosterone (481-29-8) + pregnanetetrol-(3,17,20,21) (566-41-6,977-24-2,3413-98-7,3615-89-2,22630-67-7,52152-75-7,58718-28-8,58718-29-9,58718-30-2,58718-31-3,97133-45-4)

Guidance literature:

With 1,4-dioxane; potassium hydroxide; at 140 - 160 ℃; (20Ξ)-5α,17βH-pregnanetetrol-(3β,17,20,21) of mp: 211 degree;

DOI:10.1002/hlca.19470300702

Reference yield:

3β.17.21-triacetoxy-5α.17βH-pregnanone-(20) (23634-60-8,27768-98-5) → pregnanetetrol-(3,17,20,21) (566-41-6,977-24-2,3413-98-7,3615-89-2,22630-67-7,52152-75-7,58718-28-8,58718-29-9,58718-30-2,58718-31-3,97133-45-4)

Guidance literature:

With methanol; nickel; at 100 ℃; under 110326 Torr; (20Ξ)-5α,17βH-pregnanetetrol-(3β,17,20,21) of mp: 248 degree; Hydrogenation_.Kochen des Reaktionsprodukts mit methanol. KOH;

Reference yield:

→ pregnanetetrol-(3,17,20,21) (566-41-6,977-24-2,3413-98-7,3615-89-2,22630-67-7,52152-75-7,58718-28-8,58718-29-9,58718-30-2,58718-31-3,97133-45-4)

Guidance literature:

With 1,4-dioxane; potassium hydroxide; at 142 ℃; (20Ξ)-5α,17βH-pregnanetetrol-(3β,17,20,21) of mp: 248 degree;

DOI:10.1002/hlca.19470300627

upstream raw materials:

3β.17.21-triacetoxy-5α.17βH-pregnanone-(20)

1,4-dioxane

5α,17βH-pregn-20-ene-3β,17-diol

diethyl ether

Downstream raw materials:

3β,21-diacetoxy-5α-pregnan-20-one

androstanedione

formaldehyd

Epiandrosterone