Technology Process of 3-Ethoxy-2-fluoro-6-methoxyphenethylamine
There total 7 articles about 3-Ethoxy-2-fluoro-6-methoxyphenethylamine which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
lithium aluminium tetrahydride;
In
tetrahydrofuran;
for 2h;
Heating;
DOI:10.1021/jm950639r
- Guidance literature:
-
Multi-step reaction with 6 steps
1: mCPBA, MgSO4 / CHCl3 / 12 h / Ambient temperature
2: 94 percent / aq. NH3 / methanol / 1 h / Ambient temperature
3: K2CO3 / acetone / 5 h / 60 °C
4: 1.) BuLi / 1.) hexane, THF, -65 degC, 0.5 h, 2.) hexane, THF, from -65 deg C to RT
5: 1.) NaOH, 2.) 4N aq. HCl / 1.) H2O, methanol, -3 deg C, 15 min
6: LiAlH4 / tetrahydrofuran / 2 h / Heating
With
hydrogenchloride; ammonium hydroxide; sodium hydroxide; lithium aluminium tetrahydride; n-butyllithium; magnesium sulfate; potassium carbonate; 3-chloro-benzenecarboperoxoic acid;
In
tetrahydrofuran; methanol; chloroform; acetone;
DOI:10.1021/jm950639r
- Guidance literature:
-
Multi-step reaction with 4 steps
1: K2CO3 / acetone / 5 h / 60 °C
2: 1.) BuLi / 1.) hexane, THF, -65 degC, 0.5 h, 2.) hexane, THF, from -65 deg C to RT
3: 1.) NaOH, 2.) 4N aq. HCl / 1.) H2O, methanol, -3 deg C, 15 min
4: LiAlH4 / tetrahydrofuran / 2 h / Heating
With
hydrogenchloride; sodium hydroxide; lithium aluminium tetrahydride; n-butyllithium; potassium carbonate;
In
tetrahydrofuran; acetone;
DOI:10.1021/jm950639r
