167683-93-4

Basic information

• Product Name: 2-FLUORO-4-METHOXYPHENOL
• Synonyms: 2-FLUORO-4-METHOXYPHENOL;Phenol, 2-fluoro-4-methoxy- (9CI);2-Fluorohydroquinonemonomethylether(OH=1);3-Fluoro-4-hydroxyanisole;3-Fluoro-4-hydroxyanisole, 2-Fluoro-p-guaiacol
• CAS NO: 167683-93-4
• Molecular Formula: C₇H₇FO₂
• Molecular Weight: 142.13
• Product Categories: HALIDE;Aromatic Phenols;Anisoles, Alkyloxy Compounds & Phenylacetates;Fluorine Compounds;Phenols
• Mol File: 167683-93-4.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 94°C/4mmHg
• Flash Point: 100.6 °C
• Appearance: /
• Density: 1.27
• Vapor Pressure: 0.235mmHg at 25°C
• Refractive Index: 1.5240-1.5280
• Storage Temp.: 2-8°C
• PKA: 9.19±0.18(Predicted)
• CAS DataBase Reference: 2-FLUORO-4-METHOXYPHENOL(CAS DataBase Reference)
• NIST Chemistry Reference: 2-FLUORO-4-METHOXYPHENOL(167683-93-4)
• EPA Substance Registry System: 2-FLUORO-4-METHOXYPHENOL(167683-93-4)

Safety Data

• Hazard Codes: C
• Statements: 36/37/38
• Safety Statements: 26-36/37/39
• Hazardous Substances Data: 167683-93-4(Hazardous Substances Data)

Usage

General Description

2-FLUORO-4-METHOXYPHENOL, also known as p-fluoroanisole, is a chemical compound with the molecular formula C7H7FO2. It is a colorless liquid that is commonly used as an intermediate in the synthesis of various pharmaceuticals and agrochemicals. 2-FLUORO-4-METHOXYPHENOL is also utilized in the manufacturing of dyes, perfumes, and other organic compounds. It is considered to be a potentially hazardous chemical and should be handled with care, as it can cause skin and eye irritation upon contact. Additionally, it should be stored in a cool, dry, well-ventilated area away from sources of ignition.

InChI:InChI=1/C7H7FO2/c1-10-5-2-3-7(9)6(8)4-5/h2-4,9H,1H3

Upstream product

• 2105-94-4 4-bromo-2-fluorophenol 
• 124-41-4 sodium methylate 
• 74457-86-6 1-(2-fluoro-4-methoxyphenyl)-1-ethanone 
• 456-49-5 1-fluoro-3-methoxybenzene 
• 78646-39-6 2-(4-methoxyphenoxy)pyridine 
• 150-76-5 4-methoxy-phenol 
• 181305-63-5 2-fluoro-4-methoxyphenyl acetate 

Downstream Products

• 1026793-94-1 2-ethoxy-1-fluoro-4-methoxybenzene 
• 550998-23-7 trifluoromethanesulfonic acid 2-fluoro-4-methoxyphenyl ester 
• 672931-52-1 ethyl 2-(2-fluoro-4-methoxyphenoxy)-2-methylpropionate 
• 438497-28-0 2-fluoro-4-methoxy-[2-(trimethylsilyl)ethoxymethoxy]benzene 

Relevant articles and documents

Synthetic method 4 - alkoxyphenol compounds

The invention discloses a synthetic method of 4 - alkoxyphenol compounds, and belongs to the field of organic chemical synthesis. The method is as follows: An aryl alkyl ether compound is added to the sealing tube. The catalyst dimerization acetic acid rhodium and the oxidizing agent iodobenzene diethyl ester are added, a solvent trifluoroacetic anhydride is added, and the 4 -alkoxyphenol compound is prepared by heating reaction. To the invention, high regioselectivity direct hydroxylation of the aryl alkyl ether compound is realized, the application range of the substrate is wide, the yield is high, the activity after amplification reaction does not significantly decay, and higher yield is still obtained. The utility model has good practicability and industrial application prospect.

Synthesis of 2 - fluoro phenol compounds

The present invention provides a method for synthetizing a 2-fluoro phenol compound shown in a formula IV. The phenol compound shown in the formula I is prepared into a 2-pyridine oxygroup arene compound shown in a formula II through an Ullmann reaction, the 2-pyridine oxygroup arene compound shown in the formula II is mixed with a palladium catalyst, a fluorinating reagent, an additive and an organic solvent, the mixture is stirred under the temperature of 30-160 DEG C to perform a fluorination reaction to obtain an ortho-position fluoridated 2-pyridine oxygroup arene compound shown in a formula III, and the ortho-position fluoridated 2-pyridine oxygroup arene compound shown in the formula III is prepared into the 2-fluoro phenol compound shown in the formula IV through the action of alkali. The method provided by the present invention has the advantages of mild reaction conditions, simplicity in operations, good substrate adaptability, high fluorination selectivity and the like. The 2-fluoro phenol compound is shown in the figure below.

N-arylalkyl-N-heteroarylurea and guandine compounds and methods of treating HIV infection

A method for treating HIV which comprises a compound of the formula STR1 wherein A is STR2 and Zi is O, Se, NRa or C(Ra)2, and Zii is --O or (=O)2 ; wherein R1, R2, R3, and R4 are as defined in the specification.