C₂₀H₂₄F₄N₂O₃

Base Information

Chemical Name:C₂₀H₂₄F₄N₂O₃
CAS No.:1280608-09-4
Molecular Formula:C₂₀H₂₄F₄N₂O₃
Molecular Weight:416.416
Hs Code.:

C<sub>20</sub>H<sub>24</sub>F<sub>4</sub>N<sub>2</sub>O<sub>3</sub>

Synonyms:

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Chemical Property of C₂₀H₂₄F₄N₂O₃

Chemical Property:

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Technology Process of C₂₀H₂₄F₄N₂O₃

There total 6 articles about C₂₀H₂₄F₄N₂O₃ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1280608-33-4
C₁₂H₂₁FN₄O₂

: 1280608-09-4
C₂₀H₂₄F₄N₂O₃

Guidance literature:: Multi-step reaction with 4 steps

1: 10% palladium on activated charcoal; hydrogen / methanol / 23 °C

2: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / dichloromethane / 23 °C

3: trifluoroacetic acid / dichloromethane / 23 °C

4: tetrahydrofuran / 60 °C

With 10% palladium on activated charcoal; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; trifluoroacetic acid; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1016/j.bmcl.2011.01.088

Reference yield:

: (S)-tert-butyl 4-(2-amino-1-fluoroethyl)piperidine-1-carboxylate

: 1280608-09-4
C₂₀H₂₄F₄N₂O₃

Guidance literature:: Multi-step reaction with 3 steps

1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / dichloromethane / 23 °C

2: trifluoroacetic acid / dichloromethane / 23 °C

3: tetrahydrofuran / 60 °C

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; trifluoroacetic acid; In tetrahydrofuran; dichloromethane;
DOI:10.1016/j.bmcl.2011.01.088

Reference yield:

: 142374-19-4
tert-butyl 4-(formylmethyl)piperidine-1-carboxylate

: 1280608-09-4
C₂₀H₂₄F₄N₂O₃

Guidance literature:: Multi-step reaction with 7 steps

1: (5S)-5-benzyl-2,2,3-trimethylimidazolidin-4-one; N-fluorobis(benzenesulfon)imide / tetrahydrofuran; isopropyl alcohol / -15 °C

2: sodium tetrahydroborate / dichloromethane

3: diphenyl phosphoryl azide / tetrahydrofuran / 23 °C

4: 10% palladium on activated charcoal; hydrogen / methanol / 23 °C

5: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / dichloromethane / 23 °C

6: trifluoroacetic acid / dichloromethane / 23 °C

7: tetrahydrofuran / 60 °C

With sodium tetrahydroborate; diphenyl phosphoryl azide; 10% palladium on activated charcoal; hydrogen; (5S)-5-benzyl-2,2,3-trimethylimidazolidin-4-one; benzotriazol-1-ol; N-fluorobis(benzenesulfon)imide; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; trifluoroacetic acid; In tetrahydrofuran; methanol; dichloromethane; isopropyl alcohol; 3: Mitsunobu-type reaction;
DOI:10.1016/j.bmcl.2011.01.088