2-{3-[4-(2-Methoxy-phenyl)-piperazin-1-yl]-propyl}-1,2,3,4,6,7,8,9-octahydro-benzo[b][1,6]naphthyridine; compound with (E)-but-2-enedioic acid

Base Information

• Chemical Name: 2-{3-[4-(2-Methoxy-phenyl)-piperazin-1-yl]-propyl}-1,2,3,4,6,7,8,9-octahydro-benzo[b][1,6]naphthyridine; compound with (E)-but-2-enedioic acid
• CAS No.: 83082-32-0
• Molecular Formula: 2C₄H₄O₄*C₂₆H₃₆N₄O
• Molecular Weight: 652.745

Synonyms:

Chemical Property of 2-{3-[4-(2-Methoxy-phenyl)-piperazin-1-yl]-propyl}-1,2,3,4,6,7,8,9-octahydro-benzo[b][1,6]naphthyridine; compound with (E)-but-2-enedioic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-{3-[4-(2-Methoxy-phenyl)-piperazin-1-yl]-propyl}-1,2,3,4,6,7,8,9-octahydro-benzo[b][1,6]naphthyridine; compound with (E)-but-2-enedioic acid

There total 3 articles about 2-{3-[4-(2-Methoxy-phenyl)-piperazin-1-yl]-propyl}-1,2,3,4,6,7,8,9-octahydro-benzo[b][1,6]naphthyridine; compound with (E)-but-2-enedioic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1,2,3,4,6,7,8,9-octahydro-benzo[b][1,6]-naphthyridine (83137-21-7) → 2-{3-[4-(2-Methoxy-phenyl)-piperazin-1-yl]-propyl}-1,2,3,4,6,7,8,9-octahydro-benzo[b][1,6]naphthyridine; compound with (E)-but-2-enedioic acid (83082-32-0)

Guidance literature:

Multi-step reaction with 3 steps

1: 44 percent / Et₃N / ethanol / Heating

2: SOCl₂ / Ambient temperature

3: Et₃N / 1.) EtOH, reflux; 2.) acetone

With thionyl chloride; triethylamine; In ethanol;

DOI:10.1248/cpb.32.3981

Reference yield:

2-(3-hydroxypropyl)-1,2,3,4,6,7,8,9-octahydrobenzo<1,6>naphthyridine (95395-57-6) → 2-{3-[4-(2-Methoxy-phenyl)-piperazin-1-yl]-propyl}-1,2,3,4,6,7,8,9-octahydro-benzo[b][1,6]naphthyridine; compound with (E)-but-2-enedioic acid (83082-32-0)

Guidance literature:

Multi-step reaction with 2 steps

1: SOCl₂ / Ambient temperature

2: Et₃N / 1.) EtOH, reflux; 2.) acetone

With thionyl chloride; triethylamine;

DOI:10.1248/cpb.32.3981

Reference yield:

1-(2-methoxyphenyl)piperazine hydrochloride (5464-78-8) + 2-(3-Chloro-propyl)-1,2,3,4,6,7,8,9-octahydro-benzo[b][1,6]naphthyridine; hydrochloride (95395-60-1) + (2E)-but-2-enedioic acid (110-17-8,26099-09-2) → 2-{3-[4-(2-Methoxy-phenyl)-piperazin-1-yl]-propyl}-1,2,3,4,6,7,8,9-octahydro-benzo[b][1,6]naphthyridine; compound with (E)-but-2-enedioic acid (83082-32-0)

Guidance literature:

With triethylamine; 1.) EtOH, reflux; 2.) acetone;

DOI:10.1248/cpb.32.3981

upstream raw materials:

1-(2-methoxyphenyl)piperazine hydrochloride

2-(3-Chloro-propyl)-1,2,3,4,6,7,8,9-octahydro-benzo[b][1,6]naphthyridine; hydrochloride

(2E)-but-2-enedioic acid

2-(3-hydroxypropyl)-1,2,3,4,6,7,8,9-octahydrobenzo<1,6>naphthyridine

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