3-(2-bromo-4-methylphenyl)propanoic acid

Base Information

• Chemical Name: 3-(2-bromo-4-methylphenyl)propanoic acid
• CAS No.: 829-57-2
• Molecular Formula: C₁₀H₁₁BrO₂
• Molecular Weight: 243.1
• Mol file: 829-57-2.mol

Synonyms:

Chemical Property of 3-(2-bromo-4-methylphenyl)propanoic acid

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

3-(2-bromo-4-methylphenyl)propanoic acid 95 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-(2-bromo-4-methylphenyl)propanoic acid

There total 4 articles about 3-(2-bromo-4-methylphenyl)propanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

cycl-isopropylidene malonate (2033-24-1) + 2-bromo-4-methylbenzaldehyde (824-54-4) → 3-(2-bromo-4-methylphenyl)propanoic acid (829-57-2)

Guidance literature:

With formic acid; triethylamine; at 0 - 95 ℃; for 4h;

DOI:10.1021/acs.orglett.9b03498

Reference yield:

2-Brom-4-methyl-zimtsaeure (829-58-3) → 3-(2-bromo-4-methylphenyl)propanoic acid (829-57-2)

Guidance literature:

With sodium hydroxide; sodium amalgam;

Reference yield:

2-bromo-p-toluidine (583-68-6) → 3-(2-bromo-4-methylphenyl)propanoic acid (829-57-2)

Guidance literature:

Multi-step reaction with 3 steps

1: (i) (diazotization), (ii) /BRN= 1697325/, NaOAc, H₂O, (iii) aq. HCl

2: Py / 95 °C

3: Na-Hg, aq. NaOH

With pyridine; sodium hydroxide; sodium amalgam;

upstream raw materials:

2-Brom-4-methyl-zimtsaeure

2-bromo-p-toluidine

2-bromo-4-methylbenzaldehyde

cycl-isopropylidene malonate

Downstream raw materials:

3-(2-bromo-4-methylphenyl)propanol