diethyl hydroxy(3-chlorophenyl)methylphosphonate

Base Information

• Chemical Name: diethyl hydroxy(3-chlorophenyl)methylphosphonate
• CAS No.: 1244123-44-1
• Molecular Formula: C₁₁H₁₆ClO₄P
• Molecular Weight: 278.672
• Mol file: 1244123-44-1.mol

Synonyms:

Chemical Property of diethyl hydroxy(3-chlorophenyl)methylphosphonate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of diethyl hydroxy(3-chlorophenyl)methylphosphonate

There total 1 articles about diethyl hydroxy(3-chlorophenyl)methylphosphonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

m-Chlorobenzaldehyde (587-04-2) + phosphonic acid diethyl ester (762-04-9) → diethyl hydroxy(3-chlorophenyl)methylphosphonate (1244123-44-1,1012320-93-2)

Guidance literature:

With n-butyllithium; In neat (no solvent); at 20 ℃; for 0.0833333h; Catalytic behavior; Schlenk technique; Inert atmosphere;

DOI:10.1021/ol5030713

Reference yield: 98.0%

diethyl hydroxy(3-chlorophenyl)methylphosphonate (1244123-44-1,1012320-93-2) → diethyl P-(3-chlorobenzoyl)phosphonate (19957-20-1)

Guidance literature:

With nicotinium dichromate; In acetonitrile; for 0.333333h; Heating;

DOI:10.1081/SCC-120030697

Reference yield: 96.0%

diethyl hydroxy(3-chlorophenyl)methylphosphonate (1244123-44-1,1012320-93-2) + 1,1,1,3,3,3-hexamethyl-disilazane (999-97-3) → diethyl α-trimethylsilyloxy-3-chlorobenzylphosphonate

Guidance literature:

With aluminium(III) triflate; at 20 ℃; for 0.166667h;

DOI:10.1055/s-2005-861789

upstream raw materials:

m-Chlorobenzaldehyde

phosphonic acid diethyl ester

Downstream raw materials:

diethyl 3-chloro-α-fluorobenzylphosphonate

diethyl P-(3-chlorobenzoyl)phosphonate

[(3-chloro-phenyl)-hydrazino-methyl]-phosphonic acid diethyl ester

[(3-Chloro-phenyl)-fluoro-methyl]-phosphonic acid