Methanesulfonic acid 3-[(1R,6S)-2-benzenesulfonyl-6-(tert-butyl-dimethyl-silanyloxy)-2-trimethylsilanyl-cyclohexyl]-propyl ester

Base Information

• Chemical Name: Methanesulfonic acid 3-[(1R,6S)-2-benzenesulfonyl-6-(tert-butyl-dimethyl-silanyloxy)-2-trimethylsilanyl-cyclohexyl]-propyl ester
• CAS No.: 123567-99-7
• Molecular Formula: C₂₅H₄₆O₆S₂Si₂
• Molecular Weight: 562.94
• Mol file: 123567-99-7.mol

Synonyms:

Chemical Property of Methanesulfonic acid 3-[(1R,6S)-2-benzenesulfonyl-6-(tert-butyl-dimethyl-silanyloxy)-2-trimethylsilanyl-cyclohexyl]-propyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Methanesulfonic acid 3-[(1R,6S)-2-benzenesulfonyl-6-(tert-butyl-dimethyl-silanyloxy)-2-trimethylsilanyl-cyclohexyl]-propyl ester

There total 3 articles about Methanesulfonic acid 3-[(1R,6S)-2-benzenesulfonyl-6-(tert-butyl-dimethyl-silanyloxy)-2-trimethylsilanyl-cyclohexyl]-propyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

3-[(1R,6S)-2-Benzenesulfonyl-6-(tert-butyl-dimethyl-silanyloxy)-2-trimethylsilanyl-cyclohexyl]-propan-1-ol (123567-96-4,123670-10-0) + methanesulfonyl chloride (124-63-0) → Methanesulfonic acid 3-[(1R,6S)-2-benzenesulfonyl-6-(tert-butyl-dimethyl-silanyloxy)-2-trimethylsilanyl-cyclohexyl]-propyl ester (123567-99-7,123670-12-2)

Guidance literature:

With triethylamine;

DOI:10.1021/jo00288a058

Reference yield:

3-(tert-butyldimethylsilyloxy)-1-(phenylsulfonyl)cyclohexene (70810-37-6) → Methanesulfonic acid 3-[(1R,6S)-2-benzenesulfonyl-6-(tert-butyl-dimethyl-silanyloxy)-2-trimethylsilanyl-cyclohexyl]-propyl ester (123567-99-7,123670-12-2)

Guidance literature:

Multi-step reaction with 3 steps

2: 1. BH₃SMe₂ 2. 10percent H₂O₂, 10percent NaOH / 1. THF, 0 deg C - 25 deg C, 0.5 h 2. CH₂Cl₂, 0 deg C - 25 deg C, 1 h

3: 100 percent / NEt₃

With sodium hydroxide; dimethylsulfide borane complex; dihydrogen peroxide; triethylamine;

DOI:10.1021/jo00288a058

Reference yield:

[(2R,3S)-2-Allyl-3-(tert-butyl-dimethyl-silanyloxy)-1-trimethylsilanyl-cyclohexanesulfonyl]-benzene (123568-11-6,123670-09-7) → Methanesulfonic acid 3-[(1R,6S)-2-benzenesulfonyl-6-(tert-butyl-dimethyl-silanyloxy)-2-trimethylsilanyl-cyclohexyl]-propyl ester (123567-99-7,123670-12-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 1. BH₃SMe₂ 2. 10percent H₂O₂, 10percent NaOH / 1. THF, 0 deg C - 25 deg C, 0.5 h 2. CH₂Cl₂, 0 deg C - 25 deg C, 1 h

2: 100 percent / NEt₃

With sodium hydroxide; dimethylsulfide borane complex; dihydrogen peroxide; triethylamine;

DOI:10.1021/jo00288a058

upstream raw materials:

3-[(1R,6S)-2-Benzenesulfonyl-6-(tert-butyl-dimethyl-silanyloxy)-2-trimethylsilanyl-cyclohexyl]-propan-1-ol

methanesulfonyl chloride

3-(tert-butyldimethylsilyloxy)-1-(phenylsulfonyl)cyclohexene

[(2R,3S)-2-Allyl-3-(tert-butyl-dimethyl-silanyloxy)-1-trimethylsilanyl-cyclohexanesulfonyl]-benzene

Downstream raw materials:

((4aR,8aS)-5-Benzenesulfonyl-octahydro-chromen-5-yl)-trimethyl-silane

Methanesulfonic acid 3-[(1R,6S)-2-benzenesulfonyl-6-(tert-butyl-dimethyl-silanyloxy)-cyclohexyl]-propyl ester

(4aR,8aS)-5-Benzenesulfonyl-octahydro-chromene